PMID- 23277188
OWN - NLM
STAT- MEDLINE
DCOM- 20130906
LR  - 20130307
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 35
DP  - 2013 Jan-Feb
TI  - Gestational exposure to yellow fever vaccine at different developmental stages 
      induces behavioral alterations in the progeny.
PG  - 21-7
LID - S0892-0362(12)00178-X [pii]
LID - 10.1016/j.ntt.2012.12.002 [doi]
AB  - The most effective method to prevent yellow fever and control the disease is a 
      vaccine made with attenuated live virus. Due to the neurological tropism of the 
      virus, preventive vaccination is not recommended for infants under 6 months and 
      for pregnant women. However there is a paucity of data regarding the safety for 
      pregnant women and there are no experimental studies investigating adverse 
      effects to the offspring after maternal exposure to the vaccine. This study aimed 
      to investigate, in mice, the effects of maternal exposure to the yellow fever 
      vaccine at three different gestational ages on the physical and behavioral 
      development of the offspring. Pregnant Swiss mice received a single subcutaneous 
      injection of water for injection (control groups) or 2 log Plaque Forming Units 
      (vaccine-treated groups) of the yellow fever vaccine on gestational days (GD) 5, 
      10 or 15. Neither maternal signs of toxicity nor alterations in physical 
      development and reflex ontogeny of the offspring were observed in any of the 
      groups. Data from behavioral evaluation indicated that yellow fever vaccine 
      exposure induced motor hypoactivity in 22-day-old females independent of the day 
      of exposure; and in 60-day-old male and female pups exposed at GD 10. Moreover, 
      22-day-old females also presented with a deficit in habituation memory. 
      Altogether, these results indicate that in utero exposure to the yellow fever 
      vaccine may induce behavioral alterations in the pups that may persist to 
      adulthood in the absence of observed maternal toxicity or disruption of physical 
      development milestones or reflex ontogeny.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Marianno, P
AU  - Marianno P
AD  - Department of Biology, State University of Londrina (UEL), Londrina, Parana, 
      Brazil.
FAU - Salles, M J S
AU  - Salles MJ
FAU - Sonego, A B
AU  - Sonego AB
FAU - Costa, G A
AU  - Costa GA
FAU - Galvao, T C
AU  - Galvao TC
FAU - Lima, G Z
AU  - Lima GZ
FAU - Moreira, E G
AU  - Moreira EG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121229
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Yellow Fever Vaccine)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn/*growth & development/immunology
MH  - Behavior, Animal/*physiology
MH  - Developmental Disabilities/immunology/*physiopathology
MH  - Female
MH  - Gestational Age
MH  - Male
MH  - Memory Disorders/etiology
MH  - Mice
MH  - Motor Activity/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/immunology/*physiopathology
MH  - Reflex/physiology
MH  - Sex Factors
MH  - Yellow Fever Vaccine/*adverse effects
EDAT- 2013/01/02 06:00
MHDA- 2013/09/07 06:00
CRDT- 2013/01/02 06:00
PHST- 2012/07/26 00:00 [received]
PHST- 2012/12/13 00:00 [revised]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2013/01/02 06:00 [entrez]
PHST- 2013/01/02 06:00 [pubmed]
PHST- 2013/09/07 06:00 [medline]
AID - S0892-0362(12)00178-X [pii]
AID - 10.1016/j.ntt.2012.12.002 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2013 Jan-Feb;35:21-7. doi: 10.1016/j.ntt.2012.12.002. Epub 
      2012 Dec 29.