PMID- 2327831
OWN - NLM
STAT- MEDLINE
DCOM- 19900521
LR  - 20190912
IS  - 0148-5016 (Print)
IS  - 0148-5016 (Linking)
VI  - 24
IP  - 2
DP  - 1990
TI  - Testicular steroids in spermatic and peripheral veins after single injection of 
      hCG in patients with varicocele.
PG  - 207-13
AB  - To determine the function of Leydig cells in patients with varicocele, 
      hCG-stimulated levels of progesterone (Prog), 17 
      alpha-Hydroxy-4-pregnene-3,20-dione (17OHP), 4-Androstene-3,17-dione (A-dione), 
      testosterone (T), and estradiol-17 beta (E2) in both spermatic and peripheral 
      veins were measured. Seventy-two patients with idiopathic varicocele were divided 
      into four groups: patients in group 1 were untreated, whereas patients in groups 
      2, 3, and 4 were given a single i.m. injection of 10,000 IU hCG 24 h, 96 h, and 
      168 h before surgery, respectively. In the spermatic and peripheral veins, levels 
      of Prog, 17OHP, and E2 showed peaks at 24 h, whereas levels of A-dione and T 
      showed peaks at 96 h. Significant increases in the ratios of spermatic veins 
      17OHP to A-dione and 17OHP to T, and a significant decrease in the ratio of T to 
      E2, was found 24 h following hCG treatment. These results demonstrate that, 
      following hCG injection, there is a transient inhibition of testicular 
      C17-20-lyase activity, probably mediated by E2, even in subfertile males with 
      varicocele.
FAU - Takeyama, M
AU  - Takeyama M
AD  - Department of Urology and Pathology, Sakai Municipal Hospital, Japan.
FAU - Honjoh, M
AU  - Honjoh M
FAU - Kodama, M
AU  - Kodama M
FAU - Sakaguchi, H
AU  - Sakaguchi H
FAU - Koh, E
AU  - Koh E
FAU - Kondoh, N
AU  - Kondoh N
FAU - Fujioka, H
AU  - Fujioka H
FAU - Nakamura, M
AU  - Nakamura M
FAU - Namiki, M
AU  - Namiki M
FAU - Okuyama, A
AU  - Okuyama A
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Arch Androl
JT  - Archives of andrology
JID - 7806755
RN  - 0 (Chorionic Gonadotropin)
RN  - 0 (Testicular Hormones)
SB  - IM
MH  - Adult
MH  - Chorionic Gonadotropin/*pharmacology
MH  - Humans
MH  - Leydig Cells/*physiology
MH  - Male
MH  - Stimulation, Chemical
MH  - Testicular Hormones/*blood
MH  - Testis/blood supply/*drug effects/metabolism
MH  - Time Factors
MH  - Varicocele/*blood/physiopathology/surgery
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.3109/01485019008986881 [doi]
PST - ppublish
SO  - Arch Androl. 1990;24(2):207-13. doi: 10.3109/01485019008986881.