PMID- 23278570
OWN - NLM
STAT- MEDLINE
DCOM- 20130221
LR  - 20130102
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1275
DP  - 2012 Dec
TI  - IVIG and PLEX in the treatment of myasthenia gravis.
PG  - 1-6
LID - 10.1111/j.1749-6632.2012.06767.x [doi]
AB  - Intravenous immunoglobulin (IVIG) and plasma exchange (PLEX) are used to treat 
      myasthenia gravis (MG) but with little trial evidence. While a class I study 
      provided evidence for the efficacy of IVIG treatment, the empirical support for 
      PLEX has been less convincing until recently. In a randomized controlled 
      single-masked study of 84 MG patients with moderate to severe disease, IVIG and 
      PLEX had comparable efficacy as demonstrated by reduction in the Quantitative 
      Myasthenia Gravis Score (QMGS) for disease severity, percentage of responders, 
      persistence of treatment effect, and tolerability, which were similar in both 
      treatment arms. The change in QMGS was accompanied by improved disease-specific 
      quality of life. The only factor predicting response to treatment was baseline 
      severity. FcR polymorphisms did not predict response to IVIG therapy, but an 
      inhibitory polymorphism was associated with baseline disease severity. These 
      studies support the choice of either IVIG or PLEX as comparable treatments in 
      adult patients with moderate to severe MG.
CI  - (c) 2012 New York Academy of Sciences.
FAU - Bril, Vera
AU  - Bril V
AD  - Department of Medicine (Neurology), University Health Network, University of 
      Toronto, Toronto, Ontario, Canada. vera.bril@utoronto.ca
FAU - Barnett-Tapia, Carolina
AU  - Barnett-Tapia C
FAU - Barth, David
AU  - Barth D
FAU - Katzberg, Hans D
AU  - Katzberg HD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Myasthenia Gravis/physiopathology/*therapy
MH  - *Plasma Exchange
MH  - Quality of Life
MH  - Severity of Illness Index
EDAT- 2013/01/03 06:00
MHDA- 2013/02/22 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/02/22 06:00 [medline]
AID - 10.1111/j.1749-6632.2012.06767.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2012 Dec;1275:1-6. doi: 10.1111/j.1749-6632.2012.06767.x.