PMID- 23278608
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20211203
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 52
IP  - 1
DP  - 2013 Jan
TI  - Human leukocyte antigens class I and class II in patients with pemphigus in 
      southern Turkey.
PG  - 53-8
LID - 10.1111/j.1365-4632.2012.05541.x [doi]
AB  - BACKGROUND: Genetic factors that predispose individuals to pemphigus are 
      considered to play important roles in the development of the disease. 
      Furthermore, population studies of patients with pemphigus have clearly shown 
      that the most prevalent alleles differ across ethnic groups. OBJECTIVES: This 
      controlled study was designed to detect the distribution of human leukocyte 
      antigen (HLA) class I and II alleles in Turkish patients with pemphigus. METHODS: 
      Sixty patients diagnosed with pemphigus according to clinical findings, 
      histology, immunofluorescence, and enzyme-linked immunosorbent assay (ELISA) were 
      enrolled in the study. The control group consisted of 60 healthy adult transplant 
      donors. HLA typing was carried out using a polymerase chain reaction (PCR) with 
      sequence-specific primers (SSP) method. RESULTS: The frequencies of HLAs A*11, 
      CW*01, DRB1*04, DRB1*14, DQB1*05, and DPB1*0401 were found to be statistically 
      significantly higher in the disease group than in controls. By contrast, the 
      frequencies of HLAs B*18, B*50, DRB1*11, DQB1*02, DQB1*06, DPB1*0301, and 
      DPB1*1102 were statistically significantly lower in the pemphigus group than in 
      controls. Linkage dysequilibrium analysis showed that DRB1*14/DQB1*05, 
      A*11/DQB1*05, and A*11/DRB1*14 alleles were detected frequently in pemphigus 
      patients, and DRB1*11/DQB1*05, DRB1*14/DQB1*02, B*50/DQB1*02, and B*50/DPB1*0301 
      alleles appeared frequently in healthy controls. CONCLUSIONS: The results suggest 
      that DRB1*04, DRB1*14, DQB1*05, and DPB1*0401 class II HLAs and A*11 and CW*01 
      class I HLAs are associated with pemphigus in southern Turkey. Observed 
      differences in LD patterns between patients and controls suggest that the 
      coexistence of the respective alleles is strongly determinant of predisposition 
      towards (DRB1*14/DQB1*05 and A*11/DQB1*05) or protection against (B*50/DQB1*02) 
      the disease.
CI  - (c) 2013 The International Society of Dermatology.
FAU - Koc, Cilem Kaya
AU  - Koc CK
AD  - Department of Dermatology and Venereology, Akdeniz University School of Medicine, 
      Antalya, Turkey.
FAU - Sallakci, Nilgun
AU  - Sallakci N
FAU - Akman-Karakas, Ayse
AU  - Akman-Karakas A
FAU - Alpsoy, Erkan
AU  - Alpsoy E
FAU - Yegin, Olcay
AU  - Yegin O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pemphigus/*genetics
MH  - Polymerase Chain Reaction
MH  - Turkey
EDAT- 2013/01/03 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
AID - 10.1111/j.1365-4632.2012.05541.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2013 Jan;52(1):53-8. doi: 10.1111/j.1365-4632.2012.05541.x.