PMID- 23278901
OWN - NLM
STAT- MEDLINE
DCOM- 20130627
LR  - 20211203
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 22
IP  - 1
DP  - 2013 Jan
TI  - Mammalian target of rapamycin complex 1 (mTORC1) may modulate the timing of 
      anagen entry in mouse hair follicles.
PG  - 77-80
LID - 10.1111/exd.12062 [doi]
AB  - Mammalian target of rapamycin (mTOR) is a central regulator of cell proliferation 
      and survival. There is limited evidence that mTOR influences hair follicles 
      (HFs), which undergo cycles of quiescence (telogen), growth (anagen) and 
      regression (catagen). We sought to investigate whether mTOR, in particular mTOR 
      complex 1 (mTORC1), regulates the hair growth cycle by employing biochemical, 
      immunohistochemical and functional approaches in vivo. Here, we demonstrate that 
      quantitative analysis of mTORC1 kinase activity shows phase-dependent changes, 
      and phosphorylated mTOR at S2448 (p-mTOR) was localized in certain sites of HFs 
      in a phase-dependent manner. These results were indicative of mTOR's role in hair 
      growth initiation. Finally, in a pharmacological challenge in vivo using the 
      specific mTORC1 inhibitor, rapamycin, hair cycle initiation was delayed, 
      suggesting a functional relevance of mTORC1 in anagen entry. Based on our 
      findings, we propose that mTORC1 may participate in hair cycle regulation, namely 
      the timing of anagen initiation.
CI  - (c) 2013 John Wiley & Sons A/S.
FAU - Kellenberger, Antonia J
AU  - Kellenberger AJ
FAU - Tauchi, Miyuki
AU  - Tauchi M
LA  - eng
PT  - Letter
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Multiprotein Complexes)
RN  - 0 (Proteins)
RN  - EC 2.7.1.1 (mTOR protein, mouse)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Animals
MH  - Biological Clocks
MH  - Hair/growth & development
MH  - Hair Follicle/drug effects/*metabolism
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Multiprotein Complexes/*metabolism
MH  - Phosphorylation
MH  - Proteins/*metabolism
MH  - Ribosomal Protein S6 Kinases, 70-kDa/metabolism
MH  - Sirolimus/pharmacology
MH  - TOR Serine-Threonine Kinases/*metabolism
EDAT- 2013/01/03 06:00
MHDA- 2013/06/29 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/10/29 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/06/29 06:00 [medline]
AID - 10.1111/exd.12062 [doi]
PST - ppublish
SO  - Exp Dermatol. 2013 Jan;22(1):77-80. doi: 10.1111/exd.12062.