PMID- 23279093
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20220409
IS  - 1751-7133 (Electronic)
IS  - 1527-5299 (Print)
IS  - 1527-5299 (Linking)
VI  - 19
IP  - 4
DP  - 2013 Jul-Aug
TI  - Prognostic implications of relative hypochromia in ambulatory patients with 
      chronic systolic heart failure.
PG  - 180-5
LID - 10.1111/chf.12010 [doi]
AB  - Iron insufficiency has been associated with heart failure, but the impact of a 
      reduction of hemoglobin content in the erythrocytes as estimated by mean 
      corpuscular hemoglobin concentration (MCHC) to myocardial structure, performance, 
      and long-term clinical outcomes has not been well-established. The authors 
      examined hematologic data and long-term outcomes of 197 ambulatory patients with 
      chronic systolic and symptomatic heart failure who underwent comprehensive 
      echocardiographic evaluation. The authors observed that relative hypochromia 
      (defined as low MCHC) was associated with higher natriuretic peptide levels 
      (NT-proBNP, r =-0.40, P<.0001) and lower estimated glomerular filtration rate 
      (eGFR; r = 0.45, P <. 0001) and correlated modestly with indices of left and 
      right ventricular diastolic dysfunction (all P<.05), but were not related to left 
      ventricular ejection fraction (LVEF, r=0.17, P=.079). After 5 years of follow-up, 
      lower MCHC levels were associated with higher risk of death, transplant, or heart 
      failure hospitalization after adjusting for age, LVEF, eGFR, and New York Heart 
      Association class (hazard ratio, 1.34; 95% confidence interval, 1.04-1.72; 
      P=.025), particularly in those with above-median hemoglobin (>13.8 g/dL; hazard 
      ratio, 2.02; 95% confidence interval, 1.44-2.81, P<.0001). Taken together, the 
      observations imply that physicians should take notice of the presence of relative 
      hypochromia particularly in the absence of anemia in the setting of chronic 
      systolic heart failure.
CI  - (c) 2012 Wiley Periodicals, Inc.
FAU - Simbaqueba, Cesar
AU  - Simbaqueba C
AD  - Department of Medicine, Fairview Health Services, Minneapolis, MN, USA.
FAU - Shrestha, Kevin
AU  - Shrestha K
FAU - Patarroyo, Maria
AU  - Patarroyo M
FAU - Troughton, Richard W
AU  - Troughton RW
FAU - Borowski, Allen G
AU  - Borowski AG
FAU - Klein, Allan L
AU  - Klein AL
FAU - Tang, W H Wilson
AU  - Tang WH
LA  - eng
GR  - R01 HL103931/HL/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121219
PL  - United States
TA  - Congest Heart Fail
JT  - Congestive heart failure (Greenwich, Conn.)
JID - 9714174
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Anemia, Hypochromic/blood/*etiology
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure, Systolic/*complications/diagnostic imaging/physiopathology
MH  - Hemoglobins/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - *Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC3620796
MID - NIHMS413546
EDAT- 2013/01/03 06:00
MHDA- 2014/02/05 06:00
PMCR- 2014/07/01
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - 10.1111/chf.12010 [doi]
PST - ppublish
SO  - Congest Heart Fail. 2013 Jul-Aug;19(4):180-5. doi: 10.1111/chf.12010. Epub 2012 
      Dec 19.