PMID- 23279128
OWN - NLM
STAT- MEDLINE
DCOM- 20130829
LR  - 20131121
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 37
IP  - 6
DP  - 2013 Mar
TI  - Infusion of brain-derived neurotrophic factor into the ventral tegmental area 
      switches the substrates mediating ethanol motivation.
PG  - 996-1003
LID - 10.1111/ejn.12105 [doi]
AB  - Recent work has shown that infusion of brain-derived neurotrophic factor (BDNF) 
      into the ventral tegmental area (VTA) promotes a switch in the mechanisms 
      mediating morphine motivation, from a dopamine-independent to a 
      dopamine-dependent pathway. Here we showed that a single infusion of intra-VTA 
      BDNF also promoted a switch in the mechanisms mediating ethanol motivation, from 
      a dopamine-dependent to a dopamine-independent pathway (exactly opposite to that 
      seen with morphine). We suggest that intra-VTA BDNF, via its actions on TrkB 
      receptors, precipitates a switch similar to that which occurs naturally when mice 
      transit from a drug-naive, non-deprived state to a drug-deprived state. The 
      opposite switching of the mechanisms underlying morphine and ethanol motivation 
      by BDNF in previously non-deprived animals is consistent with their proposed 
      actions on VTA GABAA receptors.
CI  - (c) 2012 Federation of European Neuroscience Societies and Blackwell Publishing 
      Ltd.
FAU - Ting-A-Kee, Ryan
AU  - Ting-A-Kee R
AD  - Institute of Medical Science, University of Toronto, Toronto, ON, M5S 3E1, 
      Canada. ryan.ting.a.kee@utoronto.ca
FAU - Vargas-Perez, Hector
AU  - Vargas-Perez H
FAU - Bufalino, Mary-Rose
AU  - Bufalino MR
FAU - Bahi, Amine
AU  - Bahi A
FAU - Dreyer, Jean-Luc
AU  - Dreyer JL
FAU - Tyndale, Rachel F
AU  - Tyndale RF
FAU - van der Kooy, Derek
AU  - van der Kooy D
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121221
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, GABA-A)
RN  - 3K9958V90M (Ethanol)
RN  - 76I7G6D29C (Morphine)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Addictive/metabolism
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Conditioning, Operant
MH  - Dopamine/pharmacology
MH  - Ethanol/blood/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Morphine/pharmacology
MH  - Motivation/*drug effects
MH  - Receptor, trkB/metabolism
MH  - Receptors, GABA-A/metabolism
MH  - Ventral Tegmental Area/drug effects/metabolism/*physiology
EDAT- 2013/01/03 06:00
MHDA- 2013/08/30 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/04/17 00:00 [received]
PHST- 2012/10/26 00:00 [revised]
PHST- 2012/11/25 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/08/30 06:00 [medline]
AID - 10.1111/ejn.12105 [doi]
PST - ppublish
SO  - Eur J Neurosci. 2013 Mar;37(6):996-1003. doi: 10.1111/ejn.12105. Epub 2012 Dec 
      21.