PMID- 23279145
OWN - NLM
STAT- MEDLINE
DCOM- 20130617
LR  - 20130102
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 12
IP  - 4
DP  - 2012 Dec
TI  - Improvement in delusions and hallucinations in patients with dementia with Lewy 
      bodies upon administration of yokukansan, a traditional Japanese medicine.
PG  - 235-41
LID - 10.1111/j.1479-8301.2012.00413.x [doi]
AB  - BACKGROUND: This multicentre open-label trial examined the efficacy and safety of 
      the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for 
      behavioural and psychological symptoms of dementia (BPSD) in patients with 
      dementia with Lewy bodies. METHODS: Sixty-three dementia with Lewy bodies 
      patients with probable BPSD (M:W, 30:33; mean age, 78.2+/-5.8 years) were enrolled 
      and treated with YKS for 4 weeks. RESULTS: Significant improvements in 
      Neuropsychiatric Inventory scores (mean decrease, 12.5 points; P<0.001) and Zarit 
      Burden Interview-Japanese edition tests (mean decrease, 3.6 points; P=0.024) were 
      observed. In patients who consented to an assessment after 2 weeks of treatment, 
      a time-dependent significant improvement was observed in the Neuropsychiatric 
      Inventory score (n=23; mean decrease, 14.4; P<0.001), each subscale, including 
      delusions and hallucinations, the Zarit Burden Interview-Japanese edition (n=22; 
      mean decrease, 8.2; P<0.01) and the behavioural pathology in Alzheimer's disease 
      insomnia subscale. The Mini-Mental State Examination and the Disability 
      Assessment for Dementia (DAD) showed no significant change. Adverse events were 
      observed in 11 (18%) patients. Three patients (5%) discontinued YKS due to 
      adverse reactions, namely, spasticity and exacerbation of BPSD, edema, and 
      nausea. Hypokalaemia (<3.5 mEq/L) was present in four patients (6%) at the study 
      endpoint. Worsening of extrapyramidal symptoms was not observed. CONCLUSION: YKS 
      improved BPSD in dementia with Lewy bodies patients and caregiver burden scores 
      without deterioration in cognitive function. YKS is useful for the treatment of 
      delusions and hallucinations in BPSD.
CI  - (c) 2012 The Authors. Psychogeriatrics (c) 2012 Japanese Psychogeriatric Society.
FAU - Iwasaki, Koh
AU  - Iwasaki K
AD  - Department of Traditional Asian Medicine, Graduate School of Medicine, Tohoku 
      University, Sendai Center for Traditional Asian Medicine, Nishitaga National 
      Hospital, Sendai, Japan.
FAU - Kosaka, Kenji
AU  - Kosaka K
FAU - Mori, Hideo
AU  - Mori H
FAU - Okitsu, Reina
AU  - Okitsu R
FAU - Furukawa, Katsutoshi
AU  - Furukawa K
FAU - Manabe, Yuta
AU  - Manabe Y
FAU - Yoshita, Mitsuhiro
AU  - Yoshita M
FAU - Kanamori, Aya
AU  - Kanamori A
FAU - Ito, Nobuo
AU  - Ito N
FAU - Wada, Kenji
AU  - Wada K
FAU - Kitayama, Michio
AU  - Kitayama M
FAU - Horiguchi, Jun
AU  - Horiguchi J
FAU - Yamaguchi, Shuhei
AU  - Yamaguchi S
FAU - Takayama, Shin
AU  - Takayama S
FAU - Fukuhara, Ryuji
AU  - Fukuhara R
FAU - Ouma, Shinji
AU  - Ouma S
FAU - Nakano, Seigo
AU  - Nakano S
FAU - Hashimoto, Mamoru
AU  - Hashimoto M
FAU - Kinoshita, Toru
AU  - Kinoshita T
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Plant Extracts)
RN  - 0 (Yi-Gan San)
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Aged, 80 and over
MH  - Delusions/*drug therapy/etiology/psychology
MH  - Disability Evaluation
MH  - Drugs, Chinese Herbal/*administration & dosage/adverse effects/therapeutic use
MH  - Female
MH  - Hallucinations/*drug therapy/etiology/psychology
MH  - Humans
MH  - Lewy Body Disease/*complications/*psychology
MH  - Male
MH  - Mental Status Schedule
MH  - Neuropsychological Tests
MH  - Plant Extracts/*administration & dosage/adverse effects/therapeutic use
MH  - Treatment Outcome
EDAT- 2013/01/03 06:00
MHDA- 2013/06/19 06:00
CRDT- 2013/01/03 06:00
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/06/19 06:00 [medline]
AID - 10.1111/j.1479-8301.2012.00413.x [doi]
PST - ppublish
SO  - Psychogeriatrics. 2012 Dec;12(4):235-41. doi: 10.1111/j.1479-8301.2012.00413.x.