PMID- 23280302
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20220331
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 444
DP  - 2013 Feb 1
TI  - Airborne molds and bacteria, microbial volatile organic compounds (MVOC), 
      plasticizers and formaldehyde in dwellings in three North European cities in 
      relation to sick building syndrome (SBS).
PG  - 433-40
LID - S0048-9697(12)01477-5 [pii]
LID - 10.1016/j.scitotenv.2012.10.114 [doi]
AB  - There are few studies on associations between airborne microbial exposure, 
      formaldehyde, plasticizers in dwellings and the symptoms compatible with the sick 
      building syndrome (SBS). As a follow-up of the European Community Respiratory 
      Health Survey (ECRHS II), indoor measurements were performed in homes in three 
      North European cities. The aim was to examine whether volatile organic compounds 
      of possible microbial origin (MVOCs), and airborne levels of bacteria, molds, 
      formaldehyde, and two plasticizers in dwellings were associated with the 
      prevalence of SBS, and to study associations between MVOCs and reports on 
      dampness and mold. The study included homes from three centers included in ECRHS 
      II. A total of 159 adults (57% females) participated (19% from Reykjavik, 40% 
      from Uppsala, and 41% from Tartu). A random sample and additional homes with a 
      history of dampness were included. Exposure measurements were performed in the 
      159 homes of the participants. MVOCs were analyzed by GCMS with selective ion 
      monitoring (SIM). Symptoms were reported in a standardized questionnaire. 
      Associations were analyzed by multiple logistic regression. In total 30.8% 
      reported any SBS (20% mucosal, 10% general, and 8% dermal symptoms) and 41% of 
      the homes had a history of dampness and molds There were positive associations 
      between any SBS and levels of 2-pentanol (P=0.002), 2-hexanone (P=0.0002), 
      2-pentylfuran (P=0.009), 1-octen-3-ol (P=0.002), formaldehyde (P=0.05), and 
      2,2,4-trimethyl-1,3-pentanediol monoisobutyrate (Texanol) (P=0.05). 1-octen-3-ol 
      (P=0.009) and 3-methylfuran (P=0.002) were associated with mucosal symptoms. In 
      dwellings with dampness and molds, the levels of total bacteria (P=0.02), total 
      mold (P=0.04), viable mold (P=0.02), 3-methylfuran (P=0.008) and 
      ethyl-isobutyrate (P=0.02) were higher. In conclusion, some MVOCs like 
      1-octen-3-ol, formaldehyde and the plasticizer Texanol, may be a risk factor for 
      sick building syndrome. Moreover, concentrations of airborne molds, bacteria and 
      some other MVOCs were slightly higher in homes with reported dampness and mold.
CI  - Copyright (c) 2012 Elsevier B.V. All rights reserved.
FAU - Sahlberg, Bo
AU  - Sahlberg B
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. bo.sahlberg@medsci.uu.se
FAU - Gunnbjornsdottir, Maria
AU  - Gunnbjornsdottir M
FAU - Soon, Argo
AU  - Soon A
FAU - Jogi, Rain
AU  - Jogi R
FAU - Gislason, Thorarinn
AU  - Gislason T
FAU - Wieslander, Gunilla
AU  - Wieslander G
FAU - Janson, Christer
AU  - Janson C
FAU - Norback, Dan
AU  - Norback D
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20121229
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Furans)
RN  - 0 (Glycols)
RN  - 0 (Octanols)
RN  - 0 (Plasticizers)
RN  - 0 (Volatile Organic Compounds)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 5R72A0440N (3-methylfuran)
RN  - 6I0QAJ1JZQ (2-pentylfuran)
RN  - 6QDY60NH6N (Methyl n-Butyl Ketone)
RN  - ID6ZZH846Y (Texanol)
RN  - WXB511GE38 (1-octen-3-ol)
SB  - IM
MH  - Adult
MH  - *Air Microbiology
MH  - Air Pollution, Indoor/adverse effects/*analysis
MH  - Cities
MH  - Estonia
MH  - Female
MH  - Formaldehyde/analysis/toxicity
MH  - Fungi
MH  - Furans/analysis/toxicity
MH  - Glycols/analysis
MH  - Humans
MH  - Iceland
MH  - Male
MH  - Methyl n-Butyl Ketone/analysis/toxicity
MH  - Octanols/analysis/toxicity
MH  - Plasticizers/toxicity
MH  - Sick Building Syndrome/chemically induced/*epidemiology/*etiology
MH  - Sweden
MH  - Volatile Organic Compounds/*analysis
MH  - Young Adult
EDAT- 2013/01/03 06:00
MHDA- 2013/09/17 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/06/11 00:00 [received]
PHST- 2012/10/25 00:00 [revised]
PHST- 2012/10/25 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - S0048-9697(12)01477-5 [pii]
AID - 10.1016/j.scitotenv.2012.10.114 [doi]
PST - ppublish
SO  - Sci Total Environ. 2013 Feb 1;444:433-40. doi: 10.1016/j.scitotenv.2012.10.114. 
      Epub 2012 Dec 29.