PMID- 23280758
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20131023
IS  - 1097-0347 (Electronic)
IS  - 1043-3074 (Linking)
VI  - 35
IP  - 11
DP  - 2013 Nov
TI  - In situ mantle cell lymphoma in the nasopharynx.
PG  - E333-7
LID - 10.1002/hed.23206 [doi]
AB  - BACKGROUND: Mantle cell lymphoma (MCL) is a B-cell neoplasm with an aggressive 
      clinical course. Recently, an indolent type of MCL has been described under the 
      term in situ MCL. METHODS AND RESULTS: We report a case of a 70-year-old woman 
      who presented with nasal obstruction. A mass, located in the nasopharynx, was 
      found. Histologic examination revealed lymphoid hyperplasia characterized by CD5 
      and cyclin D1-positive mantle zone cells, findings consistent with in situ MCL. 
      Three years later, a new biopsy was performed, which showed the same histologic 
      and immunohistochemical (IHC) findings to those observed in the first biopsy. The 
      diagnosis of in situ MCL was confirmed by fluorescence in situ hybridization 
      (FISH) analysis for t(11;14). Since then, the patient has remained free of an 
      overt lymphoma. CONCLUSIONS: In situ MCL may be observed in the nasopharynx, and 
      it would be appropriate to perform cyclin D1 immunostain in cases with marked 
      follicular hyperplasia accompanied by clinical suspicion of lymphoma.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Koletsa, Triantafyllia
AU  - Koletsa T
AD  - Department of Pathology, Medical School, Aristotle University of Thessaloniki, 
      Thessaloniki, Greece.
FAU - Markou, Konstantinos
AU  - Markou K
FAU - Ouzounidou, Sevasti
AU  - Ouzounidou S
FAU - Tsiompanou, Fani
AU  - Tsiompanou F
FAU - Karkavelas, Georgios
AU  - Karkavelas G
FAU - Kostopoulos, Ioannis
AU  - Kostopoulos I
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20121222
PL  - United States
TA  - Head Neck
JT  - Head & neck
JID - 8902541
SB  - IM
MH  - Aged
MH  - Biopsy, Needle
MH  - Carcinoma in Situ/diagnosis/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngoscopy/methods
MH  - Lymphoma, Mantle-Cell/diagnosis/*pathology
MH  - Nasal Obstruction/diagnosis/etiology
MH  - Nasopharyngeal Neoplasms/diagnosis/*pathology
MH  - Neoplasm Staging
MH  - Risk Assessment
MH  - Time Factors
MH  - Tomography, X-Ray Computed/methods
MH  - *Watchful Waiting
OTO - NOTNLM
OT  - Waldeyer's ring
OT  - in situ lymphoma
OT  - in situ mantle cell lymphoma
OT  - mantle cell lymphoma
OT  - nasopharynx
EDAT- 2013/01/03 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/09/19 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - 10.1002/hed.23206 [doi]
PST - ppublish
SO  - Head Neck. 2013 Nov;35(11):E333-7. doi: 10.1002/hed.23206. Epub 2012 Dec 22.