PMID- 23281260
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20200930
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 101
IP  - 4
DP  - 2013 May
TI  - Biodegradable and bioactive porous scaffold structures prepared using fused 
      deposition modeling.
PG  - 610-9
LID - 10.1002/jbm.b.32863 [doi]
AB  - Three-dimensional printing (3DP) refers to a group of additive manufacturing 
      techniques that can be utilized in tissue engineering applications. Fused 
      deposition modeling (FDM) is a 3DP method capable of using common thermoplastic 
      polymers. However, the scope of materials applicable for FDM has not been fully 
      recognized. The purpose of this study was to examine the creation of 
      biodegradable porous scaffold structures using different materials in FDM and to 
      determine the compressive properties and the fibroblast cell response of the 
      structures. To the best of our knowledge, the printability of a 
      poly(epsilon-caprolactone)/bioactive glass (PCL/BAG) composite and 
      L-lactide/epsilon-caprolactone 75/25 mol % copolymer (PLC) was demonstrated for the 
      first time. Scanning electron microscope (SEM) images showed BAG particles at the 
      surface of the printed PCL/BAG scaffolds. Compressive testing showed the 
      possibility of altering the compressive stiffness of a scaffold without changing 
      the compressive modulus. Compressive properties were significantly dependent on 
      porosity level and structural geometry. Fibroblast proliferation was 
      significantly higher in polylactide than in PCL or PCL/BAG composite. Optical 
      microscope images and SEM images showed the viability of the cells, which 
      demonstrated the biocompatibility of the structures.
CI  - Copyright (c) 2012 Wiley Periodicals, Inc.
FAU - Korpela, Jyrki
AU  - Korpela J
AD  - Polymer Technology Research Group, School of Chemical Technology, Aalto 
      University, Aalto 00076, Finland.
FAU - Kokkari, Anne
AU  - Kokkari A
FAU - Korhonen, Harri
AU  - Korhonen H
FAU - Malin, Minna
AU  - Malin M
FAU - Narhi, Timo
AU  - Narhi T
FAU - Seppala, Jukka
AU  - Seppala J
LA  - eng
PT  - Journal Article
DEP - 20121220
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
SB  - IM
MH  - Biocompatible Materials/*chemistry
MH  - Bone and Bones/*pathology
MH  - Cell Proliferation
MH  - Cell Survival
MH  - Compressive Strength
MH  - Fibroblasts/cytology/drug effects
MH  - Gingiva/cytology
MH  - Humans
MH  - Imaging, Three-Dimensional
MH  - Materials Testing
MH  - Microscopy, Electron, Scanning
MH  - Polyesters/*chemistry
MH  - Porosity
MH  - Surface Properties
MH  - Tissue Engineering/*methods
MH  - Tissue Scaffolds/*chemistry
EDAT- 2013/01/03 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/01/03 06:00
PHST- 2012/08/13 00:00 [received]
PHST- 2012/10/24 00:00 [revised]
PHST- 2012/11/11 00:00 [accepted]
PHST- 2013/01/03 06:00 [entrez]
PHST- 2013/01/03 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1002/jbm.b.32863 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2013 May;101(4):610-9. doi: 
      10.1002/jbm.b.32863. Epub 2012 Dec 20.