PMID- 23282338
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20131121
IS  - 1708-8186 (Electronic)
IS  - 1499-2027 (Linking)
VI  - 52
IP  - 2
DP  - 2013 Feb
TI  - Refractory effects of the N1 event-related potential in experienced cochlear 
      implant patients.
PG  - 104-12
LID - 10.3109/14992027.2012.743044 [doi]
AB  - OBJECTIVE: To determine if cochlear implant (CI) patients exhibit a temporal 
      processing deficit for auditory stimuli, by examining refractory effects of the 
      N1 event-related potential (ERP) component. DESIGN: CI patients and 
      normally-hearing controls were tested in an auditory refractory period paradigm 
      while ERP recordings were collected across the scalp. Participants were presented 
      with brief 500-Hz tones that were separated by inter-stimulus intervals (ISIs) of 
      500, 1000, or 3000 ms. The amplitude of the N1 was examined as a function of ISI 
      within each group. STUDY SAMPLE: Ten adult CI patients and 13 age-matched 
      normally-hearing controls were tested. Patients had long-lasting severe or 
      profound sensorineural hearing loss prior to implantation, and a minimum of two 
      years experience with CI activation. RESULTS: Unlike normally-hearing controls, 
      CI users showed no refractory effect for tones at 500 ms ISIs compared to 1000 
      ms. However, similar to controls, recovery from refractoriness was observed in 
      anterior locations at 3000 ms. CONCLUSION: The refractory period threshold, 
      defined as the minimum ISI where different N1 amplitudes are elicited, is greater 
      than 1000 ms in CI patients; at least double that of normally-hearing controls.
FAU - Cowper-Smith, Christopher D
AU  - Cowper-Smith CD
AD  - Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Green, Janet
AU  - Green J
FAU - Maessen, Heather
AU  - Maessen H
FAU - Bance, Manohar
AU  - Bance M
FAU - Newman, Aaron J
AU  - Newman AJ
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - England
TA  - Int J Audiol
JT  - International journal of audiology
JID - 101140017
SB  - IM
MH  - Acoustic Stimulation
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Analysis of Variance
MH  - Audiometry
MH  - Auditory Cortex/*physiopathology
MH  - Case-Control Studies
MH  - Cochlear Implantation/*instrumentation
MH  - *Cochlear Implants
MH  - *Correction of Hearing Impairment
MH  - Electroencephalography
MH  - *Evoked Potentials, Auditory
MH  - Female
MH  - Hearing Loss, Sensorineural/physiopathology/psychology/*rehabilitation
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Persons With Hearing Impairments/*rehabilitation
MH  - Psychoacoustics
MH  - Reaction Time
MH  - *Refractory Period, Electrophysiological
MH  - Signal Processing, Computer-Assisted
MH  - Time Factors
MH  - Young Adult
EDAT- 2013/01/04 06:00
MHDA- 2013/06/15 06:00
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 10.3109/14992027.2012.743044 [doi]
PST - ppublish
SO  - Int J Audiol. 2013 Feb;52(2):104-12. doi: 10.3109/14992027.2012.743044. Epub 2013 
      Jan 3.