PMID- 23282404
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130104
LR  - 20230404
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 1
IP  - 6
DP  - 2008 Jun
TI  - Immune responses to inhalant allergens.
PG  - 89-95
LID - 10.1097/WOX.0b013e3181788324 [doi]
AB  - This overview describes the nature of the immune responses induced by the 
      inhalation of allergens. There is a dichotomy in that B cells have multiple 
      mechanisms that limit the amount of immunoglobulin E (IgE) antibody production, 
      whereas T-cell responses are large even in nonallergic subjects. With the 
      possible exception of responses to cat allergen, however, T cells from 
      nonallergic subjects have limited effect or function of helping IgG antibody, and 
      in house-dust mite allergy, this declines with age. Regulation by interleukin 10 
      (IL-10)-producing cells and CD25 T-regulatory cells has been proposed, but 
      critically, there is limited evidence for this, and many studies show the highest 
      IL-10 production by cells from allergic subjects. Recent studies have shown the 
      importance of nonlymphoid chemokines thymic stromal lymphopoietin and IL-27, so 
      studying responses in situ is critical. Most sources of allergens have 1 or 2 
      dominant allergens, and for house-dust mite, it has been shown that people have a 
      predictable responsiveness to high-, mid- and poor-IgE-binding proteins 
      regardless of the total size of their response. This allergen hierarchy can be 
      used to design improved allergen preparations and to investigate how antiallergen 
      responses are regulated.
FAU - Thomas, Wayne R
AU  - Thomas WR
AD  - From the Centre for Child Health Research, University of Western Australia, 
      Telethon Institute for Health Research, Western Australia.
FAU - Hales, Belinda J
AU  - Hales BJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC3650949
EDAT- 2008/06/01 00:00
MHDA- 2008/06/01 00:01
PMCR- 2008/06/01
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2008/06/01 00:00 [pubmed]
PHST- 2008/06/01 00:01 [medline]
PHST- 2008/06/01 00:00 [pmc-release]
AID - S1939-4551(19)30582-4 [pii]
AID - 1939-4551-1-6-89 [pii]
AID - 10.1097/WOX.0b013e3181788324 [doi]
PST - ppublish
SO  - World Allergy Organ J. 2008 Jun;1(6):89-95. doi: 10.1097/WOX.0b013e3181788324.