PMID- 23282588
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130104
LR  - 20180913
IS  - 1078-0998 (Print)
IS  - 1078-0998 (Linking)
VI  - 2
IP  - 4
DP  - 1996 Winter
TI  - Fecal alpha1-Antitrypsin: A Marker of Intestinal Versus Systemic Inflammation in 
      Pediatric Crohn's Disease?
PG  - 236-43
AB  - : Growth failure and malnutrition are major concerns in pediatric patients with 
      frequent relapses of Crohn's disease (CD). In search of an early, noninvasive 
      marker of relapse, we prospectively examined the relationship between levels of 
      fecal alpha1-antitrypsin (alpha1-AT) in comparison with other known inflammatory 
      parameters and disease activity using a pediatric CD Activity Index (P-CDAI), as 
      well as in relation to growth. Forty-two pediatric patients (29 M, 13 F, 7-16 
      years old, mean 12.8 years) with ileal or ileocolonic CD were prospectively 
      examined at 4 monthly intervals over a 1 year period. Median (interquartile 
      range) fecal alpha1-AT values did not differ between children in clinical relapse 
      (P-CDAI > 150, n = 10) compared with CD patients (n = 42) with quiescent disease 
      [1.84 (3.67) mg/g versus 1.55 (3.97) mg/g, respectively, p = ns]. However, 
      children with growth failure (n = 14) had a significantly higher fecal alpha1-AT 
      [3.63 (5.65) mg/g] despite clinical remission [median P-CDAI 22 (72.5)] compared 
      with those with normal growth [1.41 (1.66) mg/g, p = 0.02]. Very high fecal alpha1-AT 
      levels (>4 mg/g) were not associated with clinically active disease [median 
      P-CDAI 23 (71.5)]. Overall however, levels in CD were significantly higher than 
      that of 17 pediatric control patients with diarrheal disorders unrelated to IBD 
      [0.98 (1.21), p < 0.05]. Fecal alpha1-AT seems therefore not to be a reliable marker 
      of clinically evident disease activity, but was best correlated with chronic 
      malnutrition and subclinical disease activity.
FAU - Herzog, D
AU  - Herzog D
AD  - Divisions of Gastroenterology and *Clinical Biochemistry, Department of 
      Pediatrics, Ste-Justine Hospital, University of Montreal, Montreal, Canada.
FAU - Delvin, E
AU  - Delvin E
FAU - Seidman, E
AU  - Seidman E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Inflamm Bowel Dis
JT  - Inflammatory bowel diseases
JID - 9508162
EDAT- 1996/01/01 00:00
MHDA- 1996/01/01 00:01
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 1996/01/01 00:00 [pubmed]
PHST- 1996/01/01 00:01 [medline]
AID - 00054725-199612000-00002 [pii]
PST - ppublish
SO  - Inflamm Bowel Dis. 1996 Winter;2(4):236-43.