PMID- 23282800
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130104
LR  - 20230404
IS  - 1939-4551 (Print)
IS  - 1939-4551 (Electronic)
IS  - 1939-4551 (Linking)
VI  - 3
IP  - 9
DP  - 2010 Sep
TI  - Association of BDNF gene polymorphism with asthma in polish children.
PG  - 235-8
LID - 10.1097/WOX.0b013e3181eedb68 [doi]
AB  - Allergic asthma is associated with changes in neuronal control in the airways 
      that modulate inflammation and airway hyperresponsiveness. The link between 
      inflammation and neuronal dysfunction is provided mainly by neurotrophins, in 
      particular Brain Derived Neurotrophic Factor (BDNF). In humans, significantly 
      higher serum BDNF levels have been observed in asthmatic patients when compared 
      with healthy subjects. BDNF levels are also significantly higher in untreated 
      asthmatic patients in comparison to those treated with inhaled glucocorticoids 
      and nonasthmatic controls. Allergic inflammation increases local BDNF production 
      and its concentration correlates with clinical parameters of allergic airway 
      dysfunction. The aim of this study was to analyze the possible association of 
      BDNF gene polymorphism with susceptibility to asthma and disease severity. We 
      analyzed 146 children diagnosed with asthma and 227 children from the control 
      group. Genotyping of 4 BDNF polymorphisms (rs12273363, rs7124442, rs6265, and 
      rs2030324) was done with use of PCR-RFLP and TaqMan SNP genotyping assay. Genetic 
      association analysis was performed in Statistica. Linkage disequilibrium was 
      determined with Haploview. Single marker analysis revealed a significant 
      association of C allele of rs2030324 polymorphism with asthma susceptibility (P = 
      0.048). However, BDNF polymorphism was not associated with severe asthma. Strong 
      linkage disequilibrium was observed between all of the BDNF polymorphisms 
      analyzed grouped in one haplotype block. We found a significant association of 
      TTGC haplotype with asthma (P = 0.025). Our results suggest that genetic 
      variation in the BDNF gene may contribute to asthma susceptibility in case of 
      rs2030324 polymorphism and TTGC haplotype, however it does not influence asthma 
      severity.
FAU - Szczepankiewicz, Aleksandra
AU  - Szczepankiewicz A
AD  - From the 1Laboratory of Cellular and Molecular Analysis, Department of Pediatric 
      Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, 
      Poznan University of Medical Sciences, Poland; 2Department of Pediatric 
      Pulmonology, Allergy and Clinical Immunology, IIIrd Department of Pediatrics, 
      Poznan University of Medical Sciences, Poland.
FAU - Breborowicz, Anna
AU  - Breborowicz A
FAU - Sobkowiak, Paulina
AU  - Sobkowiak P
FAU - Popiel, Anna
AU  - Popiel A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World Allergy Organ J
JT  - The World Allergy Organization journal
JID - 101481283
PMC - PMC3651092
EDAT- 2010/09/01 00:00
MHDA- 2010/09/01 00:01
PMCR- 2010/09/01
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2010/09/01 00:00 [pubmed]
PHST- 2010/09/01 00:01 [medline]
PHST- 2010/09/01 00:00 [pmc-release]
AID - S1939-4551(19)30485-5 [pii]
AID - 1939-4551-3-9-235 [pii]
AID - 10.1097/WOX.0b013e3181eedb68 [doi]
PST - ppublish
SO  - World Allergy Organ J. 2010 Sep;3(9):235-8. doi: 10.1097/WOX.0b013e3181eedb68.