PMID- 23283138 OWN - NLM STAT- MEDLINE DCOM- 20130718 LR - 20130205 IS - 1531-7080 (Electronic) IS - 0268-4705 (Linking) VI - 28 IP - 2 DP - 2013 Mar TI - Transcatheter mitral valve-in-valve implantation: current experience and review of literature. PG - 181-6 LID - 10.1097/HCO.0b013e32835cee0e [doi] AB - PURPOSE OF REVIEW: Transcatheter mitral valve-in-valve (MVIV) implantation is an emerging technique for reoperative mitral valve replacement in high-risk patients. Clear guidelines on the use of transcatheter MVIV implantation are yet to be determined. In this review, we report our own experience as well as the recent available literature on this procedure. RECENT FINDINGS: Since 2010, four case series of three or more patients have been reported with a total number of 23 patients. We also include unpublished data of 13 additional patients, who recently had MVIV implantation at our institution. Mean age was 78.45 +/- 9.2 years with a median follow-up ranging from 70 to 357 days. Mean The Society of Thoracic Surgeons (STS) score was 14.1 +/- 7.1%. All patients were in New York Heart Association (NYHA) class III or IV. Thirty days mortality was 7.5% (n = 3) and late mortality was 10% (n = 4). All patients had improvement in postoperative NYHA class to I/II following MVIV implantation. The mitral regurgitation grade was reduced from 3+ or 4+ preoperatively to a grade of 0 or 1 postoperatively. There was no structural valve deterioration reported in the follow-up period in any of the studies. SUMMARY: The available literature supports the use of transcatheter MVIV implantation in selected high-risk patients with favorable results. Although there are no available long-term data on the procedure, the early and mid-term outcomes are excellent with no evidence of structural valve deterioration in the available follow-up period. FAU - Cheung, Anson AU - Cheung A AD - St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. acheung@providencehealth.bc.ca FAU - Al-Lawati, Ala AU - Al-Lawati A LA - eng PT - Journal Article PT - Review PL - United States TA - Curr Opin Cardiol JT - Current opinion in cardiology JID - 8608087 SB - IM MH - Aged MH - Aged, 80 and over MH - Balloon Valvuloplasty MH - Bioprosthesis MH - Female MH - Heart Valve Prosthesis MH - Heart Valve Prosthesis Implantation/*methods MH - Humans MH - Male MH - *Mitral Valve/surgery MH - Prosthesis Design MH - Reoperation MH - Thoracotomy MH - Treatment Outcome EDAT- 2013/01/04 06:00 MHDA- 2013/07/19 06:00 CRDT- 2013/01/04 06:00 PHST- 2013/01/04 06:00 [entrez] PHST- 2013/01/04 06:00 [pubmed] PHST- 2013/07/19 06:00 [medline] AID - 10.1097/HCO.0b013e32835cee0e [doi] PST - ppublish SO - Curr Opin Cardiol. 2013 Mar;28(2):181-6. doi: 10.1097/HCO.0b013e32835cee0e.