PMID- 23283466
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20190606
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Linking)
VI  - 107 Suppl 1
DP  - 2012 Dec
TI  - Association analysis of human leukocyte antigen class II (DRB1) alleles with 
      leprosy in individuals from Sao Luis, state of Maranhao, Brazil.
PG  - 150-5
LID - S0074-02762012000900022 [pii]
AB  - Epidemiological studies have demonstrated that the variability of the clinical 
      response to infection caused by Mycobacterium leprae is associated with host 
      genetic factors. The present study investigated the frequency of human leukocyte 
      antigen (HLA) class II (DRB1) alleles in patients with leprosy from Sao Luis, 
      Maranhao, Brazil. A case-control study was performed in 85 individuals with 
      leprosy and 85 healthy subjects. All samples were analysed via polymerase chain 
      reaction-sequence specific oligonucleotide probes. The HLA-DRB1*16 allele showed 
      a higher frequency in the group with leprosy [(9.41% vs. 4.12%) odds ratio (OR) = 
      2.41 95% confidence interval (CI) (0.96-6.08) p = 0.05], whereas the HLA-DRB1*11 
      allele was less frequent in the group with leprosy [(6.47% vs. 11.76%) OR = 0.51 
      95% CI (0.23-1.12) p = 0.09]. The frequency of HLA-DRB1* alleles between the 
      control group and leprosy patient subgroups presenting different forms of the 
      disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 
      1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, 
      p = 0.032) alleles were significantly more frequent in patients with different 
      clinical subtypes of leprosy. The sample size was a limitation in this study. 
      Nevertheless, the results demonstrated the existence of a genetic susceptibility 
      associated with the clinical forms of leprosy. The low frequency of the 
      HLA-DRB1*11 allele should be further studied to investigate the possible 
      protective effect of this allele.
FAU - Correa, Rita da Graca Carvalhal Frazao
AU  - Correa Rda G
AD  - Grupo de Pesquisa em Epidemiologia de Doencas Transmissiveis , Universidade 
      Federal do Maranhao, Sao Luis, MA, Brasil. profaritacarvalhal@gmail.com
FAU - de Aquino, Dorlene Maria Cardoso
AU  - de Aquino DM
FAU - Caldas, Arlene de Jesus Mendes
AU  - Caldas Ade J
FAU - Serra, Humberto de Oliveira
AU  - Serra Hde O
FAU - Silva, Fabio Franca
AU  - Silva FF
FAU - Ferreira, Maxwellem de Jesus Costa
AU  - Ferreira Mde J
FAU - Santos, Elton Jonh Freitas
AU  - Santos EJ
FAU - Mesquita, Emygdia Rosa Rego Barros Pires Leal
AU  - Mesquita ER
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Brazil
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Leprosy/*genetics/*immunology
MH  - Leukocytes/*immunology
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2013/01/11 06:00
MHDA- 2013/11/20 06:00
CRDT- 2013/01/04 06:00
PHST- 2012/02/12 00:00 [received]
PHST- 2012/07/25 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/11 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
AID - S0074-02762012000900022 [pii]
AID - 10.1590/s0074-02762012000900022 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:150-5. doi: 
      10.1590/s0074-02762012000900022.