PMID- 23283517 OWN - NLM STAT- MEDLINE DCOM- 20130906 LR - 20130313 IS - 1661-4917 (Electronic) IS - 0004-069X (Linking) VI - 61 IP - 2 DP - 2013 Apr TI - Brain-derived neurotrophic factor in neuroimmunology: lessons learned from multiple sclerosis patients and experimental autoimmune encephalomyelitis models. PG - 95-105 LID - 10.1007/s00005-012-0211-0 [doi] AB - The concept of neuroprotective autoimmunity implies that immune cells, especially autoantigen-specific T cells, infiltrate the central nervous system (CNS) after injury and contribute to neuroregeneration and repair by secreting soluble factors. Amongst others, neurotrophic factors and neurotrophins such as brain-derived neurotropic factor (BDNF) are considered to play an important role in this process. New data raise the possibility that this concept could also be extended to neuroinflammatory diseases such as multiple sclerosis (MS) where autoantigen-specific T cells infiltrate the CNS, causing axonal/neuronal damage on the one hand, but also providing neuroprotective support on the other hand. In this review, we summarize the current knowledge on BDNF levels analyzed in MS patients in different compartments and its correlation with clinical parameters. Furthermore, new approaches in experimental animal models are discussed that attempt to decipher the functional relevance of BDNF in autoimmune demyelination. FAU - Luhder, Fred AU - Luhder F AD - Department of Neuroimmunology, Institute for Multiple Sclerosis Research and The Hertie Foundation, University Medical Center Gottingen, Waldweg 33, 37073 Gottingen, Germany. fred.luehder@med.uni-goettingen.de FAU - Gold, Ralf AU - Gold R FAU - Flugel, Alexander AU - Flugel A FAU - Linker, Ralf A AU - Linker RA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20130103 PL - Poland TA - Arch Immunol Ther Exp (Warsz) JT - Archivum immunologiae et therapiae experimentalis JID - 0114365 RN - 0 (Autoantigens) RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Autoantigens/immunology MH - Brain-Derived Neurotrophic Factor/*immunology MH - Disease Models, Animal MH - Encephalomyelitis, Autoimmune, Experimental/*immunology MH - Humans MH - Mice MH - Multiple Sclerosis/*immunology EDAT- 2013/01/04 06:00 MHDA- 2013/09/07 06:00 CRDT- 2013/01/04 06:00 PHST- 2012/06/22 00:00 [received] PHST- 2012/12/20 00:00 [accepted] PHST- 2013/01/04 06:00 [entrez] PHST- 2013/01/04 06:00 [pubmed] PHST- 2013/09/07 06:00 [medline] AID - 10.1007/s00005-012-0211-0 [doi] PST - ppublish SO - Arch Immunol Ther Exp (Warsz). 2013 Apr;61(2):95-105. doi: 10.1007/s00005-012-0211-0. Epub 2013 Jan 3.