PMID- 23283567
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20211021
IS  - 1873-1953 (Electronic)
IS  - 1474-5151 (Print)
IS  - 1474-5151 (Linking)
VI  - 12
IP  - 5
DP  - 2013 Oct
TI  - Dose-dependent relationship of physical and depressive symptoms with 
      health-related quality of life in patients with heart failure.
PG  - 454-60
LID - 10.1177/1474515112470996 [doi]
AB  - BACKGROUND: Patients with heart failure (HF) have poor health-related quality of 
      life (HRQOL). The vast majority of patients have physical symptoms, and about 
      30-40% have depressive symptoms. The combined effects of physical and depressive 
      symptoms on HRQOL have not been examined fully in HF. PURPOSES: To examine the 
      combined effects of physical and depressive symptoms on HRQOL using repeated 
      measures, controlling for covariates (i.e. age, education level, New York Heart 
      Association (NYHA) functional class, financial status, and health perception). 
      METHODS: Patients (N = 224, 62 +/- 12 years old, 67% male, 38% NYHA functional 
      class III/IV) provided data on physical (Symptom Status Questionnaire) and 
      depressive symptoms (Beck Depression Inventory II) at baseline and HRQOL 
      (Minnesota Living with Heart Failure Questionnaire) at baseline and 12 months. 
      Patients were divided into three groups based on presence of physical and 
      depressive symptoms: a) no symptom group, b) one symptom group (dyspnea or 
      fatigue), and c) two symptom group (physical and depressive symptoms). Repeated 
      measures ANOVA was used to analyze the data. RESULTS: The least squares mean 
      scores of baseline and 12-month HRQOL differed significantly in the three groups 
      after controlling for the covariates (26.4 vs. 36.6 vs. 53.1, respectively, all 
      pairwise p values < 0.001). There was no time-by-group interaction or time main 
      effect. CONCLUSION: Physical and depressive symptoms have a dose-response 
      relationship with HRQOL. Further research is needed to provide effective 
      interventions to improve physical and depressive symptoms, in turn, HRQOL.
FAU - Heo, Seongkum
AU  - Heo S
AD  - 1University of Arkansas for Medical Sciences, College of Nursing, USA.
FAU - Moser, Debra K
AU  - Moser DK
FAU - Pressler, Susan J
AU  - Pressler SJ
FAU - Dunbar, Sandra B
AU  - Dunbar SB
FAU - Kim, JinShil
AU  - Kim J
FAU - Ounpraseuth, Songthip
AU  - Ounpraseuth S
FAU - Lennie, Terry A
AU  - Lennie TA
LA  - eng
GR  - M01 RR002602/RR/NCRR NIH HHS/United States
GR  - P20 NR010679/NR/NINR NIH HHS/United States
GR  - R01 NR009280/NR/NINR NIH HHS/United States
GR  - 1P20NR010679/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130102
PL  - England
TA  - Eur J Cardiovasc Nurs
JT  - European journal of cardiovascular nursing
JID - 101128793
SB  - IM
MH  - Aged
MH  - Cardiovascular Nursing/*methods
MH  - Depression/nursing/*psychology
MH  - Female
MH  - Heart Failure/nursing/*physiopathology/*psychology
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - *Motor Activity
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
PMC - PMC4012026
MID - NIHMS575379
OTO - NOTNLM
OT  - Heart failure
OT  - depressive symptoms
OT  - quality of life
OT  - symptoms
COIS- Declaration of Conflicting Interests 'The Author(s) declare(s) that there is no 
      conflict of interest'.
EDAT- 2013/01/04 06:00
MHDA- 2014/05/20 06:00
PMCR- 2014/10/01
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
PHST- 2014/10/01 00:00 [pmc-release]
AID - 1474515112470996 [pii]
AID - 10.1177/1474515112470996 [doi]
PST - ppublish
SO  - Eur J Cardiovasc Nurs. 2013 Oct;12(5):454-60. doi: 10.1177/1474515112470996. Epub 
      2013 Jan 2.