PMID- 23283688
OWN - NLM
STAT- MEDLINE
DCOM- 20141128
LR  - 20240331
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 24
IP  - 5
DP  - 2014 May
TI  - Common variants in psychiatric risk genes predict brain structure at birth.
PG  - 1230-46
LID - 10.1093/cercor/bhs401 [doi]
AB  - Studies in adolescents and adults have demonstrated that polymorphisms in 
      putative psychiatric risk genes are associated with differences in brain 
      structure, but cannot address when in development these relationships arise. To 
      determine if common genetic variants in disrupted-in-schizophrenia-1 (DISC1; 
      rs821616 and rs6675281), catechol-O-methyltransferase (COMT; rs4680), neuregulin 
      1 (NRG1; rs35753505 and rs6994992), apolipoprotein E (APOE; epsilon3epsilon4 vs. epsilon3epsilon3), 
      estrogen receptor alpha (ESR1; rs9340799 and rs2234693), brain-derived 
      neurotrophic factor (BDNF; rs6265), and glutamate decarboxylase 1 (GAD1; 
      rs2270335) are associated with individual differences in brain tissue volumes in 
      neonates, we applied both automated region-of-interest volumetry and tensor-based 
      morphometry to a sample of 272 neonates who had received high-resolution magnetic 
      resonance imaging scans. ESR1 (rs9340799) predicted intracranial volume. Local 
      variation in gray matter (GM) volume was significantly associated with 
      polymorphisms in DISC1 (rs821616), COMT, NRG1, APOE, ESR1 (rs9340799), and BDNF. 
      No associations were identified for DISC1 (rs6675281), ESR1 (rs2234693), or GAD1. 
      Of note, neonates homozygous for the DISC1 (rs821616) serine allele exhibited 
      numerous large clusters of reduced GM in the frontal lobes, and neonates 
      homozygous for the COMT valine allele exhibited reduced GM in the temporal cortex 
      and hippocampus, mirroring findings in adults. The results highlight the 
      importance of prenatal brain development in mediating psychiatric risk.
FAU - Knickmeyer, Rebecca C
AU  - Knickmeyer RC
AD  - Department of Psychiatry.
FAU - Wang, Jiaping
AU  - Wang J
FAU - Zhu, Hongtu
AU  - Zhu H
FAU - Geng, Xiujuan
AU  - Geng X
FAU - Woolson, Sandra
AU  - Woolson S
FAU - Hamer, Robert M
AU  - Hamer RM
FAU - Konneker, Thomas
AU  - Konneker T
FAU - Lin, Weili
AU  - Lin W
FAU - Styner, Martin
AU  - Styner M
FAU - Gilmore, John H
AU  - Gilmore JH
LA  - eng
GR  - MH092335/MH/NIMH NIH HHS/United States
GR  - R01 MH086633/MH/NIMH NIH HHS/United States
GR  - HD03110/HD/NICHD NIH HHS/United States
GR  - EB005149/EB/NIBIB NIH HHS/United States
GR  - RR025747/RR/NCRR NIH HHS/United States
GR  - P01CA142538/CA/NCI NIH HHS/United States
GR  - P01 CA142538/CA/NCI NIH HHS/United States
GR  - AG033387/AG/NIA NIH HHS/United States
GR  - MH070890/MH/NIMH NIH HHS/United States
GR  - MH086633/MH/NIMH NIH HHS/United States
GR  - R01 MH091645/MH/NIMH NIH HHS/United States
GR  - MH083045/MH/NIMH NIH HHS/United States
GR  - R01 MH092335/MH/NIMH NIH HHS/United States
GR  - MH091645/MH/NIMH NIH HHS/United States
GR  - MH064065/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130102
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 1)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain/*growth & development/*pathology
MH  - Brain Mapping
MH  - *Child of Impaired Parents
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Variation/*genetics
MH  - Genotype
MH  - Glutamate Decarboxylase/genetics
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Mental Disorders/*genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - Young Adult
PMC - PMC3977618
OTO - NOTNLM
OT  - catechol-O-methyltransferase
OT  - cortex
OT  - disrupted-in-schizophrenia-1
OT  - neonate
OT  - neuroimaging
EDAT- 2013/01/04 06:00
MHDA- 2014/12/15 06:00
PMCR- 2015/05/01
CRDT- 2013/01/04 06:00
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - bhs401 [pii]
AID - 10.1093/cercor/bhs401 [doi]
PST - ppublish
SO  - Cereb Cortex. 2014 May;24(5):1230-46. doi: 10.1093/cercor/bhs401. Epub 2013 Jan 
      2.