PMID- 23284260
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20211021
IS  - 1516-8484 (Print)
IS  - 1806-0870 (Electronic)
IS  - 1516-8484 (Linking)
VI  - 33
IP  - 2
DP  - 2011
TI  - Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic 
      stem cell transplantation.
PG  - 126-30
LID - 10.5581/1516-8484.20110033 [doi]
AB  - Hematopoietic stem cell transplantation is the treatment of choice for many 
      hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. 
      Human leukocyte antigen (HLA) compatibility is an important tool to prevent 
      post-transplant complications such as graft rejection and graft-versus-host 
      disease, but the high rates of relapse limit the survival of transplant patients. 
      Natural Killer cells, a type of lymphocyte that is a key element in the defense 
      against tumor cells, cells infected with viruses and intracellular microbes, have 
      different receptors on their surfaces that regulate their cytotoxicity. Killer 
      immunoglobulin-like receptors are the most important, interacting consistently 
      with human leukocyte antigen class I molecules present in other cells and thus 
      controlling the activation of natural killer cells. Several studies have shown 
      that certain combinations of killer immunoglobulin-like receptors and human 
      leukocyte antigens (in both donors and recipients) can affect the chances of 
      survival of transplant patients, particularly in relation to the 
      graft-versusleukemia effect, which may be associated to decreased relapse rates 
      in certain groups. This review aims to shed light on the mechanisms and effects 
      of killer immunoglobulin-like receptors - human leukocyte antigen associations 
      and their implications following hematopoietic stem cell transplantation, and to 
      critically analyze the results obtained by the studies presented herein.
FAU - Franceschi, Danilo Santana Alessio
AU  - Franceschi DS
AD  - Clinical Analysis Department, Universidade Estadual de Maringa - UEM, Maringa, 
      PR, Brazil.
FAU - de Souza, Carmino Antonio
AU  - de Souza CA
FAU - Aranha, Francisco Jose Penteado
AU  - Aranha FJ
FAU - Cardozo, Daniela Maira
AU  - Cardozo DM
FAU - Sell, Ana Maria
AU  - Sell AM
FAU - Visentainer, Jeane Eliete Laguila
AU  - Visentainer JE
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Hematol Hemoter
JT  - Revista brasileira de hematologia e hemoterapia
JID - 101220159
PMC - PMC3520637
OTO - NOTNLM
OT  - Graft vs host disease
OT  - HLA antigens
OT  - Hematopoietic stem cell/transplantation
OT  - Histocompatibility testing
OT  - Killer cells, natural
OT  - Receptor KIR/immunology;
COIS- Conflict-of-interest disclosure: The authors declare no competing financial 
      interest
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2011/01/01
CRDT- 2013/01/04 06:00
PHST- 2010/04/03 00:00 [received]
PHST- 2011/01/26 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.5581/1516-8484.20110033 [doi]
PST - ppublish
SO  - Rev Bras Hematol Hemoter. 2011;33(2):126-30. doi: 10.5581/1516-8484.20110033.