PMID- 23285257
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20240318
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 7
IP  - 12
DP  - 2012
TI  - Differential response of hippocampal subregions to stress and learning.
PG  - e53126
LID - 10.1371/journal.pone.0053126 [doi]
LID - e53126
AB  - The hippocampus has two functionally distinct subregions-the dorsal portion, 
      primarily associated with spatial navigation, and the ventral portion, primarily 
      associated with anxiety. In a prior study of chronic unpredictable stress (CUS) 
      in rodents, we found that it selectively enhanced cellular plasticity in the 
      dorsal hippocampal subregion while negatively impacting it in the ventral. In the 
      present study, we determined whether this adaptive plasticity in the dorsal 
      subregion would confer CUS rats an advantage in a spatial task-the radial arm 
      water maze (RAWM). RAWM exposure is both stressful and requires spatial 
      navigation, and therefore places demands simultaneously upon both hippocampal 
      subregions. Therefore, we used Western blotting to investigate differential 
      expression of plasticity-associated proteins (brain derived neurotrophic factor 
      [BDNF], proBDNF and postsynaptic density-95 [PSD-95]) in the dorsal and ventral 
      subregions following RAWM exposure. Lastly, we used unbiased stereology to 
      compare the effects of CUS on proliferation, survival and neuronal 
      differentiation of cells in the dorsal and ventral hippocampal subregions. We 
      found that CUS and exposure to the RAWM both increased corticosterone, indicating 
      that both are stressful; nevertheless, CUS animals had significantly better 
      long-term spatial memory. We also observed a subregion-specific pattern of 
      protein expression following RAWM, with proBDNF increased in the dorsal and 
      decreased in the ventral subregion, while PSD-95 was selectively upregulated in 
      the ventral. Finally, consistent with our previous study, we found that CUS most 
      negatively affected neurogenesis in the ventral (compared to the dorsal) 
      subregion. Taken together, our data support a dual role for the hippocampus in 
      stressful experiences, with the more resilient dorsal portion undergoing adaptive 
      plasticity (perhaps to facilitate escape from or neutralization of the stressor), 
      and the ventral portion involved in affective responses.
FAU - Hawley, Darby F
AU  - Hawley DF
AD  - Department of Psychology, University of Houston, Houston, Texas, United States of 
      America.
FAU - Morch, Kristin
AU  - Morch K
FAU - Christie, Brian R
AU  - Christie BR
FAU - Leasure, J Leigh
AU  - Leasure JL
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121228
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Hippocampus/anatomy & histology/cytology/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Maze Learning/physiology
MH  - Memory/physiology
MH  - Neurogenesis/physiology
MH  - Neuronal Plasticity/physiology
MH  - Rats
MH  - Rats, Long-Evans
MH  - Spatial Behavior/physiology
MH  - Stress, Psychological/*physiopathology
MH  - Swimming/physiology
PMC - PMC3532167
COIS- Competing Interests: Please note that co-author Brian R. Christie is a PLOS ONE 
      Editorial Board member. This does not alter the authors' adherence to all the 
      PLOS ONE policies on sharing data and materials.
EDAT- 2013/01/04 06:00
MHDA- 2013/07/24 06:00
PMCR- 2012/12/28
CRDT- 2013/01/04 06:00
PHST- 2012/08/21 00:00 [received]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2013/01/04 06:00 [entrez]
PHST- 2013/01/04 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
PHST- 2012/12/28 00:00 [pmc-release]
AID - PONE-D-12-25256 [pii]
AID - 10.1371/journal.pone.0053126 [doi]
PST - ppublish
SO  - PLoS One. 2012;7(12):e53126. doi: 10.1371/journal.pone.0053126. Epub 2012 Dec 28.