PMID- 23285957
OWN - NLM
STAT- MEDLINE
DCOM- 20130516
LR  - 20161125
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 26
IP  - 19
DP  - 2012 Oct
TI  - [Expression and clinicopathological significance of foxM1 gene in laryngeal 
      squamous cell carcinoma].
PG  - 897-900
AB  - OBJECTIVE: To investigate the expression of Forkhead Box M1 transcription factor 
      (FoxM1) mRNA and protein in laryngeal squamous cell carcinoma (LSCC) and its 
      clinical significance. METHOD: Immunohistochemistry was used to examine the 
      expression of FoxM1 in 89 LSCC tissues, 89 adjacent normal tissues and 20 
      laryngeal papilloma (LP) tissues. Reverse transcriptase polymerase chain reaction 
      (RT-PCR) was used to examine the expression of FoxM1 in 20 LSCC tissues, 20 LP 
      tissues and 20 adjacent normal tissues. The relationship between FoxM1 expression 
      and the clinicopathological parameters of LSCC were analyzed. RESULT: FoxM1 mRNA 
      and protein expression were gradually decreased from LSCC to LP and normal 
      tissues. The difference was significant (P<0.05). There was a significantly 
      correlation between FoxM1 and histologic differentiation, T stage, lymph node 
      metastasis and clinical stage. Tumors with poorer differentiation, in higher T 
      stage, with lymph node metastasis or in higher clinical stage presented higher 
      FoxM1 expression than tumors with better differentiation, in lower T stage, 
      without lymph node metastasis or in lower clinical stage (P<0.05). The positive 
      expression of FoxM1 was not related with the age, gender or primary site of LSCC 
      patients (P>0.05). CONCLUSION: The up-regulation of FoxM1 may play an important 
      role in the invasion and metastasis of LSCC.
FAU - Jiang, Lizhu
AU  - Jiang L
AD  - Department of Otolaryngology, Dazu People's Hospital, Chongqing, 402360, China.
FAU - Wang, Peng
AU  - Wang P
FAU - Chen, Hongyan
AU  - Chen H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (FOXM1 protein, human)
RN  - 0 (Forkhead Box Protein M1)
RN  - 0 (Forkhead Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Forkhead Box Protein M1
MH  - Forkhead Transcription Factors/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
EDAT- 2013/01/05 06:00
MHDA- 2013/05/17 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/05/17 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Oct;26(19):897-900.