PMID- 23285970
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 9
DP  - 2012 Sep
TI  - [Determination of fungicide anilinopyrimidine residues in food by series solid 
      phase extraction-high performance liquid chromatography-tandem mass 
      spectrometry].
PG  - 896-902
AB  - A high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/ MS) 
      method was established for the determination of fungicide anilinopyrimidine 
      residues including pyrimethanil, mepanipyrim, and cyprodinil in foodstuffs with 
      series solid phase extraction (SPE). The food sample was first extracted with 
      ethyl acetate, and then purified by an ENVI-Carb cartridge and a Florisil SPE 
      cartridge. The analytes were determined by HPLC-MS/MS and quantified by external 
      standard method. The mass spectrometric detection was operated with electrospray 
      in positive ionization mode and the fungicide anilinopyrimidines were identified 
      in multiple reaction monitoring (MRM) mode. The linear range of the method was 1 
      - 20 microg/L, with the correlation coefficient (r2) over 0. 999 0. The 
      transitions of the precursor ions to two selected product ions were involved, in 
      which one group for quantification were m/z 200. 1/107. 1 for pyrimethanil, m/z 
      224. 0/106. 0 for mepanipyrim and m/z 226. 0/108. 1 for cyprodinil, and the other 
      group for identification were m/z 200. 1/183. 1 for pyrimethanil, m/z 224. 0/131. 
      1 for mepanipyrim and m/z 226. 0/133. 1 for cyprodinil, respectively. No 
      significant matrix effect was found for spiked samples after the purification. 
      The recoveries of the fungicide anilinopyrimidines spiked in food samples were 
      73.2% -98.7% at the spiked levels of 0. 1, 0.5, 1.0 microg/kg. The relative 
      standard deviations (RSDs) were less than 10%. The limits of detection (LODs) and 
      limits of quantification (LOQs) were 0. 03 microg/kg and 0.1 microg/kg for the 
      three fungicides, respectively. The results showed that the proposed method is 
      sensitive and accurate for the determination of fungicide anilinopyrimidines in 
      foodstuffs. The method should be applicable for routine analysis of pyrimethanil, 
      mepanipyrim, cyprodinil residues in foodstuffs.
FAU - Chen, Dajie
AU  - Chen D
AD  - Inspection and Quarantine Technology Center, Xiamen Entry-Exit Inspection and 
      Quarantine Bureau, Xiamen 361026, China.
FAU - Zhang, Zhigang
AU  - Zhang Z
FAU - Zhou, Yu
AU  - Zhou Y
FAU - Xiao, Zongyuan
AU  - Xiao Z
FAU - Xu, Dunming
AU  - Xu D
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Aniline Compounds)
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Pyrimidines)
RN  - 42P6T6OFWZ (cyprodinil)
RN  - 6IA5HP6C8Z (pyrimethanil)
RN  - B150X76OJY (mepanipyrim)
SB  - IM
MH  - Aniline Compounds/analysis
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drug Residues/analysis
MH  - Food Contamination/*analysis
MH  - Fruit/chemistry
MH  - Fungicides, Industrial/*analysis
MH  - Pyrimidines/*analysis
MH  - Solid Phase Extraction/methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Vegetables/chemistry
EDAT- 2013/01/05 06:00
MHDA- 2013/08/27 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.3724/sp.j.1123.2012.05003 [doi]
PST - ppublish
SO  - Se Pu. 2012 Sep;30(9):896-902. doi: 10.3724/sp.j.1123.2012.05003.