PMID- 23285972
OWN - NLM
STAT- MEDLINE
DCOM- 20130826
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 30
IP  - 9
DP  - 2012 Sep
TI  - [Simultaneous determination of 29 veterinary drugs in compound feeds by ultra 
      performance liquid chromatography-electrospray ionization tandem quadrupole mass 
      spectrometry].
PG  - 908-14
AB  - An ultra performance liquid chromatography with electrospray ionization tandem 
      mass spectrometry (UPLC-ESI-MS/MS) method was developed for the simultaneous 
      determination of 29 veterinary drugs of quinolones, sulfonamides, macrolides and 
      nitrofurans in compound feeds. The sample was extracted with 
      methanol-acetonitrile ( 1 : 1, v/v), and then cleaned up using solid phase 
      extraction with an Oasis HLB column, detected by UPLC-ESI-MS/ MS. The UPLC 
      separation was performed on a C18 column (100 mm x 2.1 mm, 1.7 microm) using a 
      gradient elution with the mobile phases of methanol and 0. 1% (v/v) formic acid 
      aqueous solution. The ESI-MS/MS detection was achieved in positive mode under 
      multiple reaction monitoring (MRM) mode. The linear ranges were from 0.01 to 5.0 
      mg/L with the correlation coefficients above 0. 99 for all the 29 veterinary 
      drugs. The average recoveries of the 29 veterinary drugs spiked in three feed 
      matrixes (the compound premix feed, the complete formula feed and the 
      concentrated feed) at four spiked levels were 61.2% - 94.3% with the relative 
      standard deviations (RSDs) of 2.2% - 15.0%. The limits of detection were 0. 01 
      mg/kg or 0.05 mg/kg. The method is rapid, accurate, reproducible, sensitive and 
      easy to apply, and suitable for the simultaneous determination of diverse 
      veterinary drugs in compound feeds.
FAU - Zhao, Ying
AU  - Zhao Y
AD  - Shenyang Entry-Exist Inspection and Quarantine Bureau, Shenyang 110016, China. 
      zy-ciq@163.com
FAU - Liu, Yu
AU  - Liu Y
FAU - Jin, Yan
AU  - Jin Y
FAU - Xu, Yihong
AU  - Xu Y
FAU - Zhong, Yu
AU  - Zhong Y
FAU - Jiang, Shi
AU  - Jiang S
FAU - Li, Xiaodong
AU  - Li X
FAU - Zeng, Fan
AU  - Zeng F
FAU - Zhou, Jiannan
AU  - Zhou J
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Macrolides)
RN  - 0 (Quinolones)
RN  - 0 (Sulfonamides)
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animal Feed/*analysis
MH  - Animals
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Drug Residues/*analysis
MH  - Macrolides/analysis
MH  - Quinolones/analysis
MH  - Spectrometry, Mass, Electrospray Ionization/methods
MH  - Sulfonamides/analysis
MH  - Tandem Mass Spectrometry/*methods
MH  - Veterinary Drugs/*analysis
EDAT- 2013/01/05 06:00
MHDA- 2013/08/27 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/08/27 06:00 [medline]
AID - 10.3724/sp.j.1123.2012.06019 [doi]
PST - ppublish
SO  - Se Pu. 2012 Sep;30(9):908-14. doi: 10.3724/sp.j.1123.2012.06019.