PMID- 23286257
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20131121
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 25
IP  - 1
DP  - 2013 Jan
TI  - Administration of additional analgesics can decrease the incidence of paradoxical 
      reactions in patients under benzodiazepine-induced sedation during endoscopic 
      transpapillary procedures: prospective randomized controlled trial.
PG  - 53-9
LID - 10.1111/j.1443-1661.2012.01325.x [doi]
AB  - AIM: The aim of the present study was to evaluate the efficacy and safety of 
      giving pentazocine as an analgesic with benzodiazepine during endoscopic 
      retrograde cholangiopancreatography (ERCP). METHODS: The paradoxical reactions 
      (PR) incidence was evaluated as an indicator of usefulness. Transcutaneous 
      arterial carbon dioxide tension (PtcCO(2) ) was evaluated as an indicator of 
      safety. A total of 160 patients were enrolled. Subjects were randomly divided 
      into two groups; group 1 sedated with midazolam only and group 2 sedated both 
      with midazolam and pentazocine (7.5 mg). RESULTS: The initial dosage introduced 
      sedation before procedure was significantly higher in group 1. The occurrence 
      rate of PR's in group 1 was significantly higher compared to that in group 2 (P = 
      0.0108). Although maximum PtcCO(2) observed during sedation did not differ 
      between the two groups (48.7 +/- 7.2, 50.3 +/- 7.6 mmHg, respectively),maximum 
      PtcCO(2) during the first 15 min after the start of sedation was significantly 
      higher in group 2 than in group 1 (P = 0.0294). In multivariate analysis, 
      procedure duration (odds ratio [OR] = 1.048) and midazolam dose (OR = 1.221) were 
      predictive factors for PR. CONCLUSION: The administration of pentazocine is 
      significantly reduced the incidence of PR's in patients under midazolam induced 
      sedation during ERCP.
CI  - (c) 2012 The Authors. Digestive Endoscopy (c) 2012 Japan Gastroenterological 
      Endoscopy Society.
FAU - Terui, Torahiko
AU  - Terui T
AD  - Department of Gastroenterology and Hepatology, Iwate Medical University, Morioka, 
      Japan.
FAU - Inomata, Masaaki
AU  - Inomata M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20120611
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Hypnotics and Sedatives)
RN  - R60L0SM5BC (Midazolam)
RN  - RP4A60D26L (Pentazocine)
SB  - IM
MH  - Adjuvants, Anesthesia/administration & dosage/*adverse effects
MH  - Aged
MH  - Analysis of Variance
MH  - *Cholangiopancreatography, Endoscopic Retrograde
MH  - Conscious Sedation/*adverse effects
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Hypercapnia
MH  - Hypnotics and Sedatives/administration & dosage/*adverse effects
MH  - Incidence
MH  - Logistic Models
MH  - Male
MH  - Midazolam/administration & dosage/*adverse effects
MH  - Middle Aged
MH  - Pentazocine/administration & dosage/*adverse effects
EDAT- 2013/01/05 06:00
MHDA- 2013/06/15 06:00
CRDT- 2013/01/05 06:00
PHST- 2012/01/27 00:00 [received]
PHST- 2012/03/26 00:00 [accepted]
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 10.1111/j.1443-1661.2012.01325.x [doi]
PST - ppublish
SO  - Dig Endosc. 2013 Jan;25(1):53-9. doi: 10.1111/j.1443-1661.2012.01325.x. Epub 2012 
      Jun 11.