PMID- 23287634
OWN - NLM
STAT- MEDLINE
DCOM- 20130430
LR  - 20130226
IS  - 1479-6805 (Electronic)
IS  - 0022-0795 (Linking)
VI  - 216
IP  - 3
DP  - 2013 Mar
TI  - Prenatal undernutrition and postnatal overnutrition alter thyroid hormone axis 
      function in sheep.
PG  - 389-402
LID - 10.1530/JOE-12-0389 [doi]
AB  - Mounting evidence led us to hypothesize that i) function of the thyroid hormone 
      (TH) axis can be programed by late gestation undernutrition (LG-UN) and ii) 
      early-postnatal-life overnutrition (EL-ON) exacerbates the fetal impacts on TH 
      axis function. In a 2 x 2 factorial experiment, 21 twin-bearing sheep were fed 
      one of two diets during late gestation: NORM (fulfilling energy and protein 
      requirements) or LOW (50% of NORM). From day 3 to 6 months after birth (around 
      puberty), the twin lambs were assigned to each their diet: conventional (CONV) or 
      high-carbohydrate, high-fat, where after half the lambs were killed. Remaining 
      sheep (exclusively females) were fed the same moderate diet until 2 years of age 
      (young adults). At 6 months and 2 years of age, fasting challenges were conducted 
      and target tissues were collected at autopsy. LG-UN caused adult hyperthyroidism 
      associated with increased thyroid expression of genes regulating TH synthesis and 
      deiodination. In one or more of the target tissues, liver, cardiac muscle, and 
      longissimus dorsi muscle, gene expressions were increased by LG-UN for TH 
      receptors (THRA and THRB) and deiodinases but were decreased in visceral and 
      subcutaneous adipose tissues. EL-ON increased TH levels in adolescent lambs, but 
      this was reversed after diet correction and not evident in adulthood. We conclude 
      that LG-UN programed TH axis function at the secretory level and differentially 
      in target tissues, which was increasingly manifested with age. Differential TH 
      signaling in adipose vs other tissues may be part of a mechanism whereby fetal 
      malnutrition can predispose for obesity and other metabolic disorders.
FAU - Johnsen, L
AU  - Johnsen L
AD  - Department of Veterinary Clinical and Animal Sciences, Faculty of Health and 
      Medical Sciences, University of Copenhagen, Groennegaardsvej 7, DK-1870 
      Frederiksberg, Denmark.
FAU - Kongsted, A H
AU  - Kongsted AH
FAU - Nielsen, M O
AU  - Nielsen MO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130225
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Malnutrition/blood/*physiopathology
MH  - Overnutrition/blood/*physiopathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/blood/*physiopathology
MH  - Receptors, Thyroid Hormone/genetics/metabolism
MH  - Sheep
MH  - Thyroid Gland/metabolism/*physiopathology
MH  - Thyroid Hormones/*blood
EDAT- 2013/01/05 06:00
MHDA- 2013/05/01 06:00
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/05/01 06:00 [medline]
AID - JOE-12-0389 [pii]
AID - 10.1530/JOE-12-0389 [doi]
PST - epublish
SO  - J Endocrinol. 2013 Feb 25;216(3):389-402. doi: 10.1530/JOE-12-0389. Print 2013 
      Mar.