PMID- 23288489
OWN - NLM
STAT- MEDLINE
DCOM- 20130514
LR  - 20211021
IS  - 1530-8561 (Electronic)
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 59
IP  - 3
DP  - 2013 Mar
TI  - Prospective evaluation of B-type natriuretic peptide concentrations and the risk 
      of type 2 diabetes in women.
PG  - 557-65
LID - 10.1373/clinchem.2012.194167 [doi]
AB  - BACKGROUND: Animal data suggest that natriuretic peptides play an important role 
      in energy metabolism, but prospective studies evaluating a relationship between 
      these peptides and type 2 diabetes mellitus (T2DM) in humans are few and results 
      are conflicting. METHODS: We used a prospective case-cohort approach (n = 491 
      T2DM cases, n = 561 reference subcohort) within the Women's Health Study to 
      evaluate baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) 
      concentrations and the risk of incident T2DM. We also tested for associations 
      between 4 common variants in the natriuretic peptide A and B genes (NPPA and 
      NPPB) and NT-proBNP concentrations (n = 458) and incident T2DM (n = 1372 cases 
      among 22 607 women). RESULTS: Case subjects had higher median baseline body mass 
      index (29.4 vs 25.0 kg/m(2), P < 0.001) and lower baseline median (interquartile 
      range) NT-proBNP concentrations [46.8 ng/L (26.1-83.2) vs 66.7 ng/L (39.3-124.7), 
      P < 0.001]. In proportional hazards models adjusting for established diabetes 
      risk factors, women in the highest quartile of baseline NT-proBNP concentration 
      (>/= 117.4 ng/L) had a 49% reduction in risk of T2DM [hazard ratio (HR) 0.51, 
      0.30-0.86, P = 0.01] relative to those in the lowest quartile. Two of the 4 
      tested variants in NPPA and NPPB (rs632793, rs198389) were associated with 
      increased NT-proBNP concentrations and reduced risk of T2DM. For example, each 
      copy of the minor allele of rs632793 was associated with increased NT-proBNP [beta 
      (SE) = 0.201 (0.063), P < 0.01] and decreased T2DM risk (HR 0.91, 0.84-0.989, P = 
      0.026). CONCLUSIONS: NT-proBNP concentrations that are high, but still within the 
      reference interval, associate with reduced risk of incident diabetes in women and 
      support a favorable role for natriuretic peptides in the prevention of T2DM.
FAU - Everett, Brendan M
AU  - Everett BM
AD  - Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical 
      School, Boston, MA 02115, USA.
FAU - Cook, Nancy R
AU  - Cook NR
FAU - Chasman, Daniel I
AU  - Chasman DI
FAU - Magnone, Maria C
AU  - Magnone MC
FAU - Bobadilla, Maria
AU  - Bobadilla M
FAU - Rifai, Nader
AU  - Rifai N
FAU - Ridker, Paul M
AU  - Ridker PM
FAU - Pradhan, Aruna D
AU  - Pradhan AD
LA  - eng
GR  - HL-099355/HL/NHLBI NIH HHS/United States
GR  - R01 HL043851/HL/NHLBI NIH HHS/United States
GR  - CA-047988/CA/NCI NIH HHS/United States
GR  - HL-043851/HL/NHLBI NIH HHS/United States
GR  - R01 HL080467/HL/NHLBI NIH HHS/United States
GR  - R01 HL103742/HL/NHLBI NIH HHS/United States
GR  - RC1 HL099355/HL/NHLBI NIH HHS/United States
GR  - R01 CA047988/CA/NCI NIH HHS/United States
GR  - HL-080467/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (NPPA protein, human)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Atrial Natriuretic Factor/genetics
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/*etiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Risk
PMC - PMC3694412
MID - NIHMS487055
EDAT- 2013/01/05 06:00
MHDA- 2013/05/15 06:00
PMCR- 2014/03/01
CRDT- 2013/01/05 06:00
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/05/15 06:00 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - clinchem.2012.194167 [pii]
AID - 10.1373/clinchem.2012.194167 [doi]
PST - ppublish
SO  - Clin Chem. 2013 Mar;59(3):557-65. doi: 10.1373/clinchem.2012.194167. Epub 2013 
      Jan 3.