PMID- 23289000
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20211021
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 10
IP  - 1
DP  - 2013
TI  - The therapeutic effect of human adult stem cells derived from adipose tissue in 
      endotoxemic rat model.
PG  - 8-18
LID - 10.7150/ijms.5385 [doi]
AB  - Excessive systemic inflammation following sepsis, trauma or burn could lead to 
      multi-organ damage and death. Bone marrow stromal cells (BMSCs), commonly 
      referred to as mesenchymal stem cells (MSCs), has been studied in several 
      immune-associated diseases in human and animal by modulating the inflammatory 
      response. Adipose tissue derived mesenchymal stem cells (ATSCs), which can be 
      obtained more easily, compared with BMSCs, has emerged as an attractive 
      alternative MSCs source for cell therapy. We investigated the therapeutic effects 
      of human ATSCs (hATSCs) in endotoxemic rat model and their capacity to modulate 
      the inflammatory response. Endotoxemia was induced with Lipopolysaccaride 
      intravenously injection (LPS, 10mg/kg). Animals were divided into the following 
      three groups: (1) saline + saline (n=5), (2) LPS + saline (n=5) and (3) LPS + 
      hATSCs (2x10(6)) (n=5). The administration of LPS caused a consistent systemic 
      inflammatory responses, increased concentrations of the pro-inflammatory 
      cytokines that have an important role in sepsis. Treatment of endotoxemia with 
      hATSCs decreased the level of inflammatory cytokines both in serum and in the 
      lung, reduced inflammatory changes in the lung, prevented apoptosis in the kidney 
      and improved multi-organ injury. In conclusion, our data demonstrates that hATSCs 
      regulate the immue/inflammatory responses and improve multi-organ injury and they 
      could be attractive candidates for cell therapy to treat endotoxemia.
FAU - Shin, Soyoung
AU  - Shin S
AD  - Department of Laboratory Medicine, The Catholic University of Korea, College of 
      Medicine, Seoul, Republic of Korea.
FAU - Kim, Yonggoo
AU  - Kim Y
FAU - Jeong, Sikyoung
AU  - Jeong S
FAU - Hong, Sungyoup
AU  - Hong S
FAU - Kim, Insoo
AU  - Kim I
FAU - Lee, Woonjeong
AU  - Lee W
FAU - Choi, Seungphil
AU  - Choi S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121206
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Lipopolysaccharides)
SB  - IM
MH  - Adipose Tissue/cytology
MH  - Adult Stem Cells/*cytology/transplantation
MH  - Animals
MH  - Cell- and Tissue-Based Therapy
MH  - Disease Models, Animal
MH  - *Endotoxemia/chemically induced/pathology/therapy
MH  - Humans
MH  - *Inflammation/chemically induced/pathology/therapy
MH  - Lipopolysaccharides/toxicity
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Rats
PMC - PMC3534872
OTO - NOTNLM
OT  - Adipose tissue derived mesenchymal stem cells(ATSCs)
OT  - Endotoxemia
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2013/01/05 06:00
MHDA- 2013/07/16 06:00
PMCR- 2013/01/01
CRDT- 2013/01/05 06:00
PHST- 2012/10/15 00:00 [received]
PHST- 2012/12/02 00:00 [accepted]
PHST- 2013/01/05 06:00 [entrez]
PHST- 2013/01/05 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - ijmsv10p0008 [pii]
AID - 10.7150/ijms.5385 [doi]
PST - ppublish
SO  - Int J Med Sci. 2013;10(1):8-18. doi: 10.7150/ijms.5385. Epub 2012 Dec 6.