PMID- 23289912
OWN - NLM
STAT- MEDLINE
DCOM- 20140116
LR  - 20220318
IS  - 1525-1470 (Electronic)
IS  - 0736-8046 (Linking)
VI  - 30
IP  - 3
DP  - 2013 May-Jun
TI  - Vitamin D level in children is correlated with severity of atopic dermatitis but 
      only in patients with allergic sensitizations.
PG  - 359-63
LID - 10.1111/pde.12058 [doi]
AB  - Vitamin D is believed to affect the progression and severity of atopic dermatitis 
      (AD). Allergic sensitization may cause this effect to vary. Individuals who 
      fulfilled the Hanifin and Rajka criteria for AD underwent epidermal prick tests 
      and blood tests for specific immunoglobulin E(IgE), serum total IgE, 25-hydroxy 
      vitamin D, and peripheral blood eosinophil count and percentage. Disease severity 
      was determined according to the Scoring Atopic Dermatitis (SCORAD) index. 
      Patients were grouped according to allergic sensitization. Seventy-three children 
      with AD (median age 33.0 mos, interquartile range 19.0-61.5 mos) were enrolled in 
      the study; 33 (45.2%) were found to have allergic sensitization. In this group 
      there was a negative correlation between SCORAD score and serum vitamin D level 
      (p = 0.047, correlation coefficient [r] = -0.349), whereas there was no 
      correlation in the group without sensitization (p = 0.30, r = -0.168). Vitamin D 
      was not correlated with total IgE and eosinophil percentage in either AD group 
      (p = 0.77, r = 0.054 and p = 0.73, r = -0.062, respectively). Vitamin D may 
      affect the severity of AD, especially in children with allergic sensitization.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Akan, Aysegul
AU  - Akan A
AD  - Department of Pediatric Allergy and Immunology, Ankara Children's Hematology 
      Oncology Education and Research Hospital, Ankara, Turkey.
FAU - Azkur, Dilek
AU  - Azkur D
FAU - Ginis, Tayfur
AU  - Ginis T
FAU - Toyran, Muge
AU  - Toyran M
FAU - Kaya, Aysenur
AU  - Kaya A
FAU - Vezir, Emine
AU  - Vezir E
FAU - Ozcan, Celal
AU  - Ozcan C
FAU - Ginis, Zeynep
AU  - Ginis Z
FAU - Kocabas, Can Naci
AU  - Kocabas CN
LA  - eng
PT  - Journal Article
DEP - 20130107
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*blood/immunology/*pathology
MH  - Eosinophils/cytology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/immunology/*pathology
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Male
MH  - Severity of Illness Index
MH  - Skin Tests
MH  - Vitamin D/*blood
MH  - Vitamin D Deficiency/*blood/immunology
EDAT- 2013/01/08 06:00
MHDA- 2014/01/17 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/17 06:00 [medline]
AID - 10.1111/pde.12058 [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2013 May-Jun;30(3):359-63. doi: 10.1111/pde.12058. Epub 2013 
      Jan 7.