PMID- 23289977
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20220317
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 23
IP  - 4
DP  - 2013 Jul
TI  - Glioblastoma with oligodendroglioma component (GBM-O): molecular genetic and 
      clinical characteristics.
PG  - 454-61
LID - 10.1111/bpa.12018 [doi]
AB  - Glioblastoma (GBM) is an aggressive primary brain tumor with an average survival 
      of approximately 1 year. A recently recognized subtype, glioblastoma with 
      oligodendroglioma component (GBM-O), was designated by the World Health 
      Organization (WHO) in 2007. We investigated GBM-Os for their clinical and 
      molecular characteristics as compared to other forms of GBM. Tissue samples were 
      used to determine EGFR, PTEN, and 1p and 19q status by fluorescence in situ 
      hybridization (FISH); p53 and mutant IDH1 protein expression by 
      immunohistochemistry (IHC); and MGMT promoter status by methylation-specific 
      polymerase chain reaction (PCR). GBM-Os accounted for 11.9% of all GBMs. GBM-Os 
      arose in younger patients compared to other forms of GBMs (50.7 years vs. 58.7 
      years, respectively), were more frequently secondary neoplasms, had a higher 
      frequency of IDH1 mutations and had a lower frequency of PTEN deletions. Survival 
      was longer in patients with GBM-Os compared to those with other GBMs, with median 
      survivals of 16.2 and 8.1 months, respectively. Most of the survival advantage 
      for GBM-O appeared to be associated with a younger age at presentation. Among 
      patients with GBM-O, younger age at presentation and 1p deletion were most 
      significant in conferring prolonged survival. Thus, GBM-O represents a subset of 
      GBMs with distinctive morphologic, clinical and molecular characteristics.
CI  - (c) 2013 The Authors; Brain Pathology (c) 2013 International Society of 
      Neuropathology.
FAU - Appin, Christina L
AU  - Appin CL
AD  - Department of Pathology and Laboratory Medicine, Emory University School of 
      Medicine, Atlanta, GA 30322, USA.
FAU - Gao, Jingjing
AU  - Gao J
FAU - Chisolm, Candace
AU  - Chisolm C
FAU - Torian, Mike
AU  - Torian M
FAU - Alexis, Dianne
AU  - Alexis D
FAU - Vincentelli, Cristina
AU  - Vincentelli C
FAU - Schniederjan, Matthew J
AU  - Schniederjan MJ
FAU - Hadjipanayis, Costas
AU  - Hadjipanayis C
FAU - Olson, Jeffrey J
AU  - Olson JJ
FAU - Hunter, Stephen
AU  - Hunter S
FAU - Hao, Chunhai
AU  - Hao C
FAU - Brat, Daniel J
AU  - Brat DJ
LA  - eng
GR  - P30 CA138292/CA/NCI NIH HHS/United States
GR  - CA138292/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130130
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - EC 1.1.1.41 (Isocitrate Dehydrogenase)
RN  - EC 1.1.1.42. (IDH1 protein, human)
RN  - EC 2.1.1.63 (O(6)-Methylguanine-DNA Methyltransferase)
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
RN  - Chromosome 1, monosomy 1p
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Neoplasms/diagnosis/*genetics/mortality
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/genetics
MH  - DNA Methylation
MH  - ErbB Receptors/*genetics
MH  - Female
MH  - Glioblastoma/diagnosis/*genetics/mortality
MH  - Humans
MH  - Isocitrate Dehydrogenase/*genetics
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Mutation/genetics
MH  - O(6)-Methylguanine-DNA Methyltransferase/metabolism
MH  - Oligodendroglioma/diagnosis/*genetics/mortality
MH  - PTEN Phosphohydrolase/genetics
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC4868066
MID - NIHMS785133
EDAT- 2013/01/08 06:00
MHDA- 2014/01/28 06:00
PMCR- 2013/01/30
CRDT- 2013/01/08 06:00
PHST- 2012/09/22 00:00 [received]
PHST- 2012/12/22 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
PHST- 2013/01/30 00:00 [pmc-release]
AID - BPA12018 [pii]
AID - 10.1111/bpa.12018 [doi]
PST - ppublish
SO  - Brain Pathol. 2013 Jul;23(4):454-61. doi: 10.1111/bpa.12018. Epub 2013 Jan 30.