PMID- 23290274
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 99
IP  - 3
DP  - 2013 Mar
TI  - Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 
      diabetes and negatively correlated with parameters of insulin resistance.
PG  - 391-5
LID - S0168-8227(12)00491-3 [pii]
LID - 10.1016/j.diabres.2012.11.026 [doi]
AB  - AIMS: To detect plasma secreted frizzled-related protein (SFRP) 5 levels in 
      Chinese healthy, obese and type 2 diabetes mellitus (T2DM) subjects and to 
      investigate the relationships between plasma SFRP5 levels and body fat 
      parameters, insulin resistance, glucolipid metabolism and inflammation. METHODS: 
      Eighty-nine subjects with normal glucose tolerance (NGT) and 87 subjects with 
      T2DM were enrolled in this study. NGT and T2DM groups were divided into normal 
      weight (NW) and obese (OB) subgroups separately. Anthropometric parameters such 
      as body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) were 
      examined. Plasma levels of SFRP5, IL-6, glucose, serum lipid, glycated hemoglobin 
      (HbA1C) and fasting insulin (FINS) levels were measured. Insulin resistance index 
      (IR) was assessed by homeostasis model assessment (HOMA). RESULTS: Plasma SFRP5 
      levels were lower in T2DM group than in NGT group. The levels of plasma SFRP5 in 
      subjects with obesity were also lower than those in subjects with NW in both NGT 
      and T2DM groups. T2DM-OB subgroup had lower plasma SFRP5 levels than that in 
      NGT-OB subgroup. Plasma SFRP5 levels were negatively correlated with BMI, WC, 
      WHR, fasting plasma glucose, HbA1C, triglyceride (TG), FINS, HOMA-IR and IL-6. 
      Multiple stepwise regression analysis showed that HOMA-IR, BMI and TG were 
      independently related with plasma SFRP5 levels. CONCLUSIONS: Plasma levels of 
      SFRP5 were decreased in Chinese obese and T2DM subjects. SFRP5 was an independent 
      factor affecting glucolipid metabolism, inflammation and IR. It may play an 
      important role in the pathogenesis of obesity and T2DM.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Hu, Zhenping
AU  - Hu Z
AD  - Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Deng, Huacong
AU  - Deng H
FAU - Qu, Hua
AU  - Qu H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Eye Proteins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycolipids)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Proteins)
RN  - 0 (SFRP5 protein, human)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Asian People
MH  - Body Mass Index
MH  - China
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Eye Proteins/*blood
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Glycolipids/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Interleukin-6/blood
MH  - Male
MH  - Membrane Proteins/*blood
MH  - Middle Aged
MH  - Obesity/*blood
EDAT- 2013/01/08 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/01/08 06:00
PHST- 2012/08/22 00:00 [received]
PHST- 2012/10/23 00:00 [revised]
PHST- 2012/11/23 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0168-8227(12)00491-3 [pii]
AID - 10.1016/j.diabres.2012.11.026 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2013 Mar;99(3):391-5. doi: 
      10.1016/j.diabres.2012.11.026. Epub 2013 Jan 3.