PMID- 23290408
OWN - NLM
STAT- MEDLINE
DCOM- 20130307
LR  - 20191210
IS  - 0767-0974 (Print)
IS  - 0767-0974 (Linking)
VI  - 28
IP  - 12
DP  - 2012 Dec
TI  - [Caloric restriction in primates: how efficient as an anti-aging approach?].
PG  - 1081-6
LID - 10.1051/medsci/20122812018 [doi]
AB  - Caloric restriction (CR) is the only non-genetic intervention known to date to 
      slow the onset of age-related diseases and increase average and maximum lifespan 
      in several species. Its interest is continually growing, particularly for the 
      identification of mechanisms involved in increasing longevity. Unlike studies in 
      invertebrate and rodent models have provided some indication about the mechanisms 
      of the CR, the efficacy of CR as an anti-aging protocol in primates has not yet 
      been fully established. In this review we present the advantages of using non 
      human primates as relevant models to the study of human aging in general and 
      specifically in the context of therapeutic interventions applicable to humans, 
      such as CR. Through the longitudinal findings in the Grey Mouse Lemur (Microcebus 
      murinus), we stress the importance of primate studies in the context of research 
      on aging and their potential to advance the development of molecules which can 
      mimic the beneficial effects of CR, already observed in some species, without 
      imposing a reduced calorie diet.
CI  - (c) 2012 medecine/sciences - Inserm / SRMS.
FAU - Marchal, Julia
AU  - Marchal J
AD  - CNRS UMR 7179, mecanismes adaptatifs (des organismes aux communautes), Museum 
      national d'histoire naturelle, 1, avenue du Petit Chateau, 91800 Brunoy, France. 
      marchal.julia@gmail.com
FAU - Perret, Martine
AU  - Perret M
FAU - Aujard, Fabienne
AU  - Aujard F
LA  - fre
PT  - Evaluation Study
PT  - Journal Article
PT  - Review
TT  - La restriction calorique chez les primates.
DEP - 20121221
PL  - France
TA  - Med Sci (Paris)
JT  - Medecine sciences : M/S
JID - 8710980
SB  - IM
MH  - Aging/metabolism/*physiology
MH  - Aging, Premature/*therapy/veterinary
MH  - Animals
MH  - *Caloric Restriction/veterinary
MH  - Cheirogaleidae/physiology
MH  - Humans
MH  - Longevity/physiology
MH  - Macaca/physiology
MH  - Models, Animal
MH  - Primates/metabolism/*physiology
EDAT- 2013/01/08 06:00
MHDA- 2013/03/08 06:00
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/03/08 06:00 [medline]
AID - medsci20122812p1081 [pii]
AID - 10.1051/medsci/20122812018 [doi]
PST - ppublish
SO  - Med Sci (Paris). 2012 Dec;28(12):1081-6. doi: 10.1051/medsci/20122812018. Epub 
      2012 Dec 21.