PMID- 23290500
OWN - NLM
STAT- MEDLINE
DCOM- 20130718
LR  - 20171213
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 226
IP  - 2
DP  - 2013 Feb
TI  - Species variation in ABCG1 isoform expression: implications for the use of animal 
      models in elucidating ABCG1 function.
PG  - 408-11
LID - S0021-9150(12)00870-2 [pii]
LID - 10.1016/j.atherosclerosis.2012.12.009 [doi]
AB  - The ATP-binding cassette transporter G1 (ABCG1) plays an important role in 
      reverse cholesterol transport by exporting cholesterol to high density 
      lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the 
      presence or absence of twelve amino acids between the ATP cassette and the 
      transmembrane domains. Previously, the longer isoform was thought to be expressed 
      only in humans. However, here we have sequenced mRNA from various cell lines and 
      tissues and demonstrate that primates and several other species, including dog, 
      cow and cat, also express both isoforms. Furthermore, we confirm that rodents, 
      including mice, express only the short isoform of ABCG1. Considering that murine 
      models are used extensively in ABCG1-related research, this report highlights 
      that there are limitations in extrapolating results from murine models to humans.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Burns, Vicky
AU  - Burns V
AD  - School of Biotechnology and Biomolecular Sciences, The University of New South 
      Wales, Sydney, NSW 2052, Australia. vicky@student.unsw.edu.au
FAU - Sharpe, Laura J
AU  - Sharpe LJ
FAU - Gelissen, Ingrid C
AU  - Gelissen IC
FAU - Brown, Andrew J
AU  - Brown AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121219
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Animals
MH  - Cats
MH  - Cattle
MH  - Dogs
MH  - Humans
MH  - Mice
MH  - Models, Animal
MH  - Protein Isoforms/genetics
EDAT- 2013/01/08 06:00
MHDA- 2013/07/19 06:00
CRDT- 2013/01/08 06:00
PHST- 2012/10/10 00:00 [received]
PHST- 2012/11/21 00:00 [revised]
PHST- 2012/12/10 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/07/19 06:00 [medline]
AID - S0021-9150(12)00870-2 [pii]
AID - 10.1016/j.atherosclerosis.2012.12.009 [doi]
PST - ppublish
SO  - Atherosclerosis. 2013 Feb;226(2):408-11. doi: 
      10.1016/j.atherosclerosis.2012.12.009. Epub 2012 Dec 19.