PMID- 23290520
OWN - NLM
STAT- MEDLINE
DCOM- 20130321
LR  - 20221109
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 38
IP  - 1
DP  - 2013 Jan 24
TI  - Perivascular mast cells dynamically probe cutaneous blood vessels to capture 
      immunoglobulin E.
PG  - 166-75
LID - S1074-7613(12)00551-1 [pii]
LID - 10.1016/j.immuni.2012.09.022 [doi]
AB  - Mast cells are tissue-resident immune cells that play a central role in allergic 
      disease. These contributions are largely dependent on the acquisition of 
      antigen-specific immunoglobulin E (IgE). Despite this requirement, studies of 
      mast cell and IgE interactions have overlooked the mechanism by which mast cells 
      acquire IgE from the blood. To address this gap, we developed reporter IgE 
      molecules and employed imaging techniques to study mast cell function in situ. 
      Our data demonstrate that skin mast cells exhibit selective uptake of IgE based 
      on perivascular positioning. Furthermore, perivascular mast cells acquire IgE by 
      extending cell processes across the vessel wall to capture luminal IgE. These 
      data demonstrate how tissue mast cells acquire IgE and reveal a strategy by which 
      extravascular cells monitor blood contents to capture molecules central to 
      cellular function.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Cheng, Laurence E
AU  - Cheng LE
AD  - Department of Pediatrics, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Hartmann, Karin
AU  - Hartmann K
FAU - Roers, Axel
AU  - Roers A
FAU - Krummel, Matthew F
AU  - Krummel MF
FAU - Locksley, Richard M
AU  - Locksley RM
LA  - eng
GR  - AI095319/AI/NIAID NIH HHS/United States
GR  - P01 AI078869/AI/NIAID NIH HHS/United States
GR  - P01 HL024136/HL/NHLBI NIH HHS/United States
GR  - P30 DK063720/DK/NIDDK NIH HHS/United States
GR  - T32 AI007334/AI/NIAID NIH HHS/United States
GR  - AI026918/AI/NIAID NIH HHS/United States
GR  - HHMI/Howard Hughes Medical Institute/United States
GR  - HD044331/HD/NICHD NIH HHS/United States
GR  - R01 AI026918/AI/NIAID NIH HHS/United States
GR  - AI30663/AI/NIAID NIH HHS/United States
GR  - K08 AI095319/AI/NIAID NIH HHS/United States
GR  - T32 HD044331/HD/NICHD NIH HHS/United States
GR  - AI078869/AI/NIAID NIH HHS/United States
GR  - R37 AI026918/AI/NIAID NIH HHS/United States
GR  - R01 AI030663/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Nat Rev Immunol. 2013 Feb;13(2):68-9. PMID: 23334246
MH  - Animals
MH  - Cell Tracking
MH  - Immunoglobulin E/*immunology/metabolism
MH  - Immunophenotyping
MH  - Mast Cells/*immunology/metabolism
MH  - Mice
MH  - Peritoneal Cavity/cytology
MH  - Peritoneum/immunology
MH  - Protein Binding/immunology
MH  - Receptors, IgE/immunology/metabolism
MH  - Skin/*immunology/metabolism
PMC - PMC3576928
MID - NIHMS441576
COIS- The authors declare no financial conflicts of interest.
EDAT- 2013/01/08 06:00
MHDA- 2013/03/22 06:00
PMCR- 2013/07/24
CRDT- 2013/01/08 06:00
PHST- 2012/01/31 00:00 [received]
PHST- 2012/09/26 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/03/22 06:00 [medline]
PHST- 2013/07/24 00:00 [pmc-release]
AID - S1074-7613(12)00551-1 [pii]
AID - 10.1016/j.immuni.2012.09.022 [doi]
PST - ppublish
SO  - Immunity. 2013 Jan 24;38(1):166-75. doi: 10.1016/j.immuni.2012.09.022. Epub 2013 
      Jan 3.