PMID- 23290986
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20130404
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 4
DP  - 2013 Apr
TI  - Optical coherence tomography assessment of apparent foveal swelling in patients 
      with foveal sparing secondary to geographic atrophy.
PG  - 829-36
LID - S0161-6420(12)00966-9 [pii]
LID - 10.1016/j.ophtha.2012.09.054 [doi]
AB  - OBJECTIVE: To determine whether foveal swelling exists in patients with foveal 
      sparing and geographic atrophy (GA) secondary to dry age-related macular 
      degeneration (AMD) and to establish the contribution of different foveal layers 
      to this condition by use of spectral-domain optical coherence tomography 
      (SD-OCT). DESIGN: Prospective comparative case series. PARTICIPANTS: We assessed 
      patients from a longitudinal study with foveal sparing and GA secondary to AMD. 
      Of an initial sample of 108 patients, 13 eyes of 10 patients complied with the 
      inclusion criteria to study eyes in which apparent swelling would not be 
      questionable. We used a control group of 13 healthy patients to compare the 
      outcome measurements. METHODS: We acquired high-resolution SD-OCT horizontal and 
      oblique B-scans centered at the umbo. Two retinal specialists (J.M., F.T.) 
      independently classified the SD-OCT images. MAIN OUTCOME MEASURES: Difference in 
      foveal center thickness, apparent outer nuclear layer (ONL) thickness, ONL 
      thickness without Henle's fiber layer (HFL), sub-ONL thickness, and retinal 
      thickness at 1000 mum and 3500 mum from the foveal center. RESULTS: The thickness 
      at the foveal center was similar between patients with apparent foveal swelling 
      (cases) and controls without AMD (226 vs. 227 mum; P = 0.56), but the apparent ONL 
      was thicker in cases than in controls (125 vs. 114 mum; P = 0.02). However, when 
      HFL was excluded from the measurements, there was little difference in the 
      results (74 vs. 73 mum; P = 0.82). CONCLUSIONS: We found neither foveal nor ONL 
      swelling in this study. We observed HFL thickening in foveal sparing secondary to 
      GA, which might be related to swelling of the axons of the photoreceptors, or 
      Muller's cells. We also observed thinning of the retina below the external 
      limiting membrane. The clinical significance of these findings should be 
      addressed by longitudinal studies and may have specific therapeutic implications.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Mones, Jordi
AU  - Mones J
AD  - Institut de la Macula i de la Retina, Centro Medico Teknon, Barcelona, Spain. 
      jmones@institutmacularetina.com
FAU - Biarnes, Marc
AU  - Biarnes M
FAU - Trindade, Fabio
AU  - Trindade F
FAU - Arias, Luis
AU  - Arias L
FAU - Alonso, Jordi
AU  - Alonso J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130103
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Follow-Up Studies
MH  - Fovea Centralis/*pathology
MH  - Geographic Atrophy/complications/*pathology
MH  - Humans
MH  - Macular Edema/etiology/*pathology
MH  - Male
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2013/01/08 06:00
MHDA- 2013/05/23 06:00
CRDT- 2013/01/08 06:00
PHST- 2012/03/28 00:00 [received]
PHST- 2012/09/27 00:00 [revised]
PHST- 2012/09/27 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - S0161-6420(12)00966-9 [pii]
AID - 10.1016/j.ophtha.2012.09.054 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Apr;120(4):829-36. doi: 10.1016/j.ophtha.2012.09.054. Epub 
      2013 Jan 3.