PMID- 23292074
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 40
IP  - 3
DP  - 2013 Mar
TI  - A (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 
      2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano[3,2-g]-chromen-3-yl-ester, attenuates 
      the development of atopic dermatitis-like lesions in NC/Nga mice.
PG  - 2541-8
LID - 10.1007/s11033-012-2339-8 [doi]
AB  - (S)-(+)-decursin is a biological coumarin compound isolated from Angelica gigas 
      Nakai. (S)-(+)-decursin and its analogue have a variety of pharmacological 
      activities. In the present study, the anti-inflammatory effect of a 
      (S)-(+)-decursin derivative, (S)-(+)-3-(3,4-dihydroxy-phenyl)-acrylic acid 
      2,2-dimethyl-8-oxo-3,4-dihydro-2H,8H-pyrano [3,2-g]-chromen-3-yl-ester (Compound 
      6, C6), on in vitro and in vivo atopic dermatitis was investigated. C6 suppressed 
      the secretion of IL-6, IL-8, and monocyte chemotactic protein-1 increase by the 
      house dust mite extract in the eosinophilic leukemia cell line and THP-1 cells. 
      C6 inhibited the production of TARC, IL-6, and IL-8 increase by IFN-gamma and TNF-alpha 
      in the human keratinocyte cell line. In the in vivo experiment, NC/Nga mice were 
      sensitized to 2,4-dinitrochlorobenzene, and then C6 or dexamethasone (Dex) were 
      orally and dorsally administered for three weeks. C6 treatment reduced the skin 
      severity score compared with that of the control group. C6 inhibited the 
      thickening of the epidermis and inflammatory cell infiltration into the dermis by 
      evaluating the histological examination. The serum immunoglobulin E (IgE) level 
      decreased in the C6-treated group compared with that of the control group. The 
      inhibitory effect of C6 on IgE concentration was similar to that of Dex. The 
      levels of IL-4, IL-5, IL-13, and eotaxin increased after treatment with 
      concanavalin A in mouse splenocytes. The cytokine levels of the C6-treated group 
      were lower than those of the control group. Taken together, C6 may attenuate 
      atopic dermatitis-like lesions through its anti-inflammatory effect, such as 
      inhibition of IgE and inflammatory cytokines, and it may be valuable as a 
      therapeutic drug for the treatment of atopic dermatitis.
FAU - Kim, In Sik
AU  - Kim IS
AD  - Department of Biomedical Laboratory Science, School of Medicine, Eulji 
      University, Daejeon, 301-746, Republic of Korea.
FAU - Kim, Dong-Hee
AU  - Kim DH
FAU - Yun, Chi-Young
AU  - Yun CY
FAU - Lee, Ji-Sook
AU  - Lee JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130105
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Benzopyrans)
RN  - 0 (Butyrates)
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - E95RTO3YQR (decursin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/administration & dosage/*pharmacology
MH  - Benzopyrans/administration & dosage/*pharmacology
MH  - Butyrates/administration & dosage/*pharmacology
MH  - Cell Line
MH  - Cytokines/biosynthesis
MH  - Dermatitis, Atopic/chemically induced/drug therapy/immunology/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Mice
MH  - Skin/drug effects/metabolism/pathology
MH  - Spleen/cytology/drug effects/metabolism
EDAT- 2013/01/08 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/01/08 06:00
PHST- 2011/12/06 00:00 [received]
PHST- 2012/12/09 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.1007/s11033-012-2339-8 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2013 Mar;40(3):2541-8. doi: 10.1007/s11033-012-2339-8. Epub 2013 
      Jan 5.