PMID- 23292611 OWN - NLM STAT- MEDLINE DCOM- 20130528 LR - 20211021 IS - 1560-2281 (Electronic) IS - 1083-3668 (Print) IS - 1083-3668 (Linking) VI - 18 IP - 1 DP - 2013 Jan TI - Automatic retinal vessel segmentation based on active contours method in Doppler spectral-domain optical coherence tomography. PG - 16002 LID - 10.1117/1.JBO.18.1.016002 [doi] LID - 016002 AB - We achieved fast and automatic retinal vessel segmentation by employing the active contours method in Doppler spectral-domain optical coherence tomography (SD-OCT). In a typical OCT B-scan image, we first extracted the phase variations between adjacent A-lines and removed bulk motion. Then we set the initial contour as the boundary of the whole image and iterated until all of the segmented vessel contours became stabilized. Using a typical office computer, the whole segmentation took no more than 50 s, making real-time retinal vessel segmentation possible. We tested the active contours method segmentation in both controlled phantom and in vivo rodent eye images. FAU - Liu, Wenzhong AU - Liu W AD - Northwestern University, Department of Biomedical Engineering, 2145 Sheridan Road, Evanston, Illinois 60208, USA. FAU - Liu, Tan AU - Liu T FAU - Song, Wei AU - Song W FAU - Yi, Ji AU - Yi J FAU - Zhang, Hao F AU - Zhang HF LA - eng GR - R01 EY019951/EY/NEI NIH HHS/United States GR - 1RC4E021357/RC/CCR NIH HHS/United States GR - 1R01EY019951/EY/NEI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. PL - United States TA - J Biomed Opt JT - Journal of biomedical optics JID - 9605853 SB - IM MH - Algorithms MH - Animals MH - Image Processing, Computer-Assisted/*instrumentation/*methods MH - Phantoms, Imaging MH - Rats MH - Retinal Vessels/*anatomy & histology MH - Tomography, Optical Coherence/*instrumentation/*methods PMC - PMC3537324 EDAT- 2013/01/08 06:00 MHDA- 2013/05/29 06:00 PMCR- 2014/01/04 CRDT- 2013/01/08 06:00 PHST- 2013/01/08 06:00 [entrez] PHST- 2013/01/08 06:00 [pubmed] PHST- 2013/05/29 06:00 [medline] PHST- 2014/01/04 00:00 [pmc-release] AID - 1555967 [pii] AID - 12693L [pii] AID - 10.1117/1.JBO.18.1.016002 [doi] PST - ppublish SO - J Biomed Opt. 2013 Jan;18(1):16002. doi: 10.1117/1.JBO.18.1.016002.