PMID- 23292680
OWN - NLM
STAT- MEDLINE
DCOM- 20130322
LR  - 20211021
IS  - 1546-1726 (Electronic)
IS  - 1097-6256 (Linking)
VI  - 16
IP  - 2
DP  - 2013 Feb
TI  - Dual origins of the mammalian accessory olfactory bulb revealed by an 
      evolutionarily conserved migratory stream.
PG  - 157-65
LID - 10.1038/nn.3297 [doi]
AB  - The accessory olfactory bulb (AOB) is a critical olfactory structure that has 
      been implicated in mediating social behavior. It receives input from the 
      vomeronasal organ and projects to targets in the amygdaloid complex. Its anterior 
      and posterior components (aAOB and pAOB) display molecular, connectional and 
      functional segregation in processing reproductive and defensive and aggressive 
      behaviors, respectively. We observed a dichotomy in the development of the 
      projection neurons of the aAOB and pAOB in mice. We found that they had distinct 
      sites of origin and that different regulatory molecules were required for their 
      specification and migration. aAOB neurons arose locally in the rostral 
      telencephalon, similar to main olfactory bulb neurons. In contrast, pAOB neurons 
      arose caudally, from the neuroepithelium of the diencephalic-telencephalic 
      boundary, from which they migrated rostrally to reach their destination. This 
      unusual origin and migration is conserved in Xenopus, providing an insight into 
      the origin of a key component of this system in evolution.
FAU - Huilgol, Dhananjay
AU  - Huilgol D
AD  - Department of Biological Sciences, Tata Institute of Fundamental Research, 
      Mumbai, India.
FAU - Udin, Susan
AU  - Udin S
FAU - Shimogori, Tomomi
AU  - Shimogori T
FAU - Saha, Bhaskar
AU  - Saha B
FAU - Roy, Achira
AU  - Roy A
FAU - Aizawa, Shinichi
AU  - Aizawa S
FAU - Hevner, Robert F
AU  - Hevner RF
FAU - Meyer, Gundela
AU  - Meyer G
FAU - Ohshima, Toshio
AU  - Ohshima T
FAU - Pleasure, Samuel J
AU  - Pleasure SJ
FAU - Zhao, Yangu
AU  - Zhao Y
FAU - Tole, Shubha
AU  - Tole S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130106
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Luminescent Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Trp73 protein, mouse)
RN  - 0 (Tumor Protein p73)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (Cyclin-Dependent Kinase 5)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Afferent Pathways/*physiology
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - *Biological Evolution
MH  - Bromodeoxyuridine/metabolism
MH  - Cell Movement/*physiology
MH  - Cyclin-Dependent Kinase 5/genetics/metabolism
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Diencephalon/cytology/physiology
MH  - Electroporation/methods
MH  - Embryo, Mammalian
MH  - Female
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Luminescent Proteins/genetics
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Microinjections/methods
MH  - Nerve Tissue Proteins/genetics/metabolism
MH  - Neurons/*physiology
MH  - Nuclear Proteins
MH  - *Olfactory Bulb/cytology/embryology/growth & development
MH  - Oocytes
MH  - Organ Culture Techniques
MH  - Pregnancy
MH  - Telencephalon/cytology/physiology
MH  - Transcription Factors/genetics/metabolism
MH  - Tumor Protein p73
MH  - Tumor Suppressor Proteins
MH  - Vomeronasal Organ/cytology/embryology/growth & development
MH  - Xenopus
EDAT- 2013/01/08 06:00
MHDA- 2013/03/23 06:00
CRDT- 2013/01/08 06:00
PHST- 2012/10/09 00:00 [received]
PHST- 2012/12/05 00:00 [accepted]
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/03/23 06:00 [medline]
AID - nn.3297 [pii]
AID - 10.1038/nn.3297 [doi]
PST - ppublish
SO  - Nat Neurosci. 2013 Feb;16(2):157-65. doi: 10.1038/nn.3297. Epub 2013 Jan 6.