PMID- 23292714
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20211203
IS  - 1559-0755 (Electronic)
IS  - 0257-277X (Print)
IS  - 0257-277X (Linking)
VI  - 56
IP  - 1
DP  - 2013 May
TI  - Immune tolerance induced by intravenous transfer of immature dendritic cells via 
      up-regulating numbers of suppressive IL-10(+) IFN-gamma(+)-producing CD4(+) T cells.
PG  - 1-8
LID - 10.1007/s12026-012-8382-7 [doi]
AB  - Dendritic cells (DCs) regulate immunity and immune tolerance in vivo. However, 
      the mechanisms of DC-mediated tolerance have not been fully elucidated. Here, we 
      demonstrate that intravenous (i.v.) transfer of bone marrow-derived DCs pulsed 
      with myelin oligodendrocyte glycoprotein (MOG) peptide blocks the development of 
      experimental autoimmune encephalomyelitis in C57BL/6J mice. i.v. transfer of 
      MOG-pulsed DCs leads to the down-regulation of the production of IL-17A and IFN-gamma 
      and up-regulation of IL-10 secretion. The development of regulatory T cells 
      (Tregs) is facilitated via up-regulation of FoxP3 expression and production of 
      IL-10. The number of suppressive CD4(+)IL-10(+)IFN-gamma(+) T cells is also improved. 
      The expression of OX40, CD154, and CD28 is down-regulated, but the expression of 
      CD152, CD80, PD-1, ICOS, and BTLA is up-regulated on CD4(+) T cells after i.v. 
      transfer of immature DCs. The expression of CCR4, CCR5, and CCR7 on CD4(+) T 
      cells is also improved. Our results suggest that immature DCs may induce 
      tolerance via facilitating the development of CD4(+)FoxP3(+) Tregs and 
      suppressive CD4(+)IL-10(+)IFN-gamma(+) T cells in vivo.
FAU - Zhou, Fang
AU  - Zhou F
AD  - Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, 
      USA.
FAU - Ciric, Bogoljub
AU  - Ciric B
FAU - Zhang, Guang-Xian
AU  - Zhang GX
FAU - Rostami, Abdolmohamad
AU  - Rostami A
LA  - eng
GR  - R01 NS048435/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunol Res
JT  - Immunologic research
JID - 8611087
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Interleukin-17)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
RN  - 0 (Receptors, Chemokine)
RN  - 130068-27-8 (Interleukin-10)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Administration, Intravenous
MH  - Animals
MH  - Antigen Presentation
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Differentiation/immunology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology/transplantation
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/*therapy
MH  - Forkhead Transcription Factors/genetics/metabolism
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Immune Tolerance
MH  - Immunosuppression Therapy
MH  - Immunotherapy, Adoptive/*methods
MH  - Interferon-gamma/metabolism
MH  - Interleukin-10/metabolism
MH  - Interleukin-17/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Multiple Sclerosis/immunology/*therapy
MH  - Myelin-Oligodendrocyte Glycoprotein/immunology
MH  - Receptors, Chemokine/genetics/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology
PMC - PMC3628929
MID - NIHMS451196
EDAT- 2013/01/08 06:00
MHDA- 2013/12/16 06:00
PMCR- 2014/05/01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.1007/s12026-012-8382-7 [doi]
PST - ppublish
SO  - Immunol Res. 2013 May;56(1):1-8. doi: 10.1007/s12026-012-8382-7.