PMID- 2329276
OWN - NLM
STAT- MEDLINE
DCOM- 19900525
LR  - 20141120
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 144
IP  - 9
DP  - 1990 May 1
TI  - Transforming growth factor-beta 1 is a costimulator for IgA production.
PG  - 3411-6
AB  - Transforming growth factor-beta 1 (TGF-beta 1) belongs to a family of 
      polypeptides involved in the regulation of cell growth and differentiation. We 
      have examined the ability of TGF-beta 1 to regulate isotype specific Ig secretion 
      by murine spleen B cells. TGF-beta 1, in the presence of rIL-2, induced a 
      synergistic 10-fold or greater increase in IgA secretion by LPS-stimulated spleen 
      B cells. TGF-beta 1 alone had little to no effect on IgA secretion. In contrast, 
      TGF-beta 1, with or without rIL-2, markedly inhibited IgG1 and IgM secretion 
      under the same conditions. The costimulatory activity of TGF-beta 1 and rIL-2 on 
      IgA secretion was seen in cultures of surface IgA negative B cells and was 
      inhibited by anti-TGF-beta 1 antibody in a dose dependent manner. Vicia villosa 
      agglutinin non-adherent Peyer's patch T cells, which secrete IL-2, also 
      synergized with TGF-beta 1 and could substitute for the activity of LPS and rIL-2 
      on the IgA response. Finally, IL-5 added after 2 days of culture, but not at the 
      beginning of culture, synergized with TGF-beta 1 on the IgA response. These 
      studies indicate that TGF-beta 1 can interact with other lymphokines and 
      selectively modulate the IgA response.
FAU - Kim, P H
AU  - Kim PH
AD  - Department of Medicine, University of California, San Diego, La Jolla 92093.
FAU - Kagnoff, M F
AU  - Kagnoff MF
LA  - eng
GR  - DK35108/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Immunoglobulin A)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-5)
RN  - 0 (Lectins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Plant Lectins)
RN  - 0 (Receptors, Antigen, B-Cell)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Vicia lectins)
RN  - 76057-06-2 (Transforming Growth Factors)
SB  - IM
MH  - Animals
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Immunoglobulin A/*biosynthesis
MH  - In Vitro Techniques
MH  - Interleukin-2/pharmacology
MH  - Interleukin-5/pharmacology
MH  - Lectins/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - *Plant Lectins
MH  - Receptors, Antigen, B-Cell/metabolism
MH  - Recombinant Proteins
MH  - Spleen/cytology
MH  - T-Lymphocytes/immunology
MH  - Transforming Growth Factors/*pharmacology
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1990 May 1;144(9):3411-6.