PMID- 23293409
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130108
LR  - 20240505
IS  - 0300-1652 (Print)
IS  - 2229-774X (Electronic)
IS  - 0300-1652 (Linking)
VI  - 53
IP  - 3
DP  - 2012 Jul
TI  - Clinical profile and outcomes of adult patients with hyperglycemic emergencies 
      managed at a tertiary care hospital in Nigeria.
PG  - 121-5
LID - 10.4103/0300-1652.104378 [doi]
AB  - BACKGROUND: To document the clinical profile and treatment outcomes of diabetic 
      ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) managed in a 
      tertiary care hospital. MATERIALS AND METHODS: This was a retrospective review of 
      hospital records of patients with DKA and HHS admitted to a tertiary care 
      hospital over a 24-month period. Data on demographics, precipitating factors, 
      clinical features, serum electrolytes, duration of hospital admission, and 
      mortality were extracted. RESULTS: Eighty-four patients were included in the 
      study. Fifty (59.5%) were females. Ten (11.9%) persons had type 1 diabetes 
      mellitus (T1DM) and 74 (88.1%) had type 2 diabetes mellitus (T2DM). There were 35 
      cases of DKA and 49 cases of HHS. Nine patients with T1DM presented in DKA and 
      one in HHS. Forty-eight (55.2%) subjects were previously not diagnosed of 
      diabetes mellitus (DM). The mean+/-SEM age, casual blood glucose, calculated serum 
      osmolality, and duration of hospital stay of the study subjects were 50.59+/-1.63 
      years, 517.98+/-11.69 mg/dL, 313.59+/-1.62 mOsmol/L, and 18.85+/-1.78 days, 
      respectively. Patients with T2DM were significantly older than those with T1DM 
      (54.32+/-1.34 vs. 23.40+/-1.38 years, P<0.001).The precipitating factors were poor 
      drug compliance 23 (27.4%), malaria 12 (14.3), urinary tract infection 10 
      (11.9%), lobar pneumonia 4 (4.8%), and unidentifiable in 29 (34.5%). Common 
      electrolyte derangements were hyponatremia, 31 (36.9%) and hypokalemia 21 (25%). 
      Mortality rate was 3.6%. CONCLUSION: DKA is common in patients with T2DM.Over 50% 
      of the patients presenting with DKA or HHS have no previous diagnosis of DM. 
      Non-compliance, malaria, and infections are important precipitants. Mortality 
      rate is low.
FAU - Edo, Andrew E
AU  - Edo AE
AD  - Department of Medicine, University of Benin Teaching Hospital, PMB 1111, Benin 
      City, Edo State, Nigeria.
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Niger Med J
JT  - Nigerian medical journal : journal of the Nigeria Medical Association
JID - 0315137
PMC - PMC3531028
OTO - NOTNLM
OT  - Diabetic ketoacidosis
OT  - hyperosmolar hyperglycemic state
OT  - precipitating factors
COIS- Conflict of Interest: None declared.
EDAT- 2013/01/08 06:00
MHDA- 2013/01/08 06:01
PMCR- 2012/07/01
CRDT- 2013/01/08 06:00
PHST- 2013/01/08 06:00 [entrez]
PHST- 2013/01/08 06:00 [pubmed]
PHST- 2013/01/08 06:01 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - NMJ-53-121 [pii]
AID - 10.4103/0300-1652.104378 [doi]
PST - ppublish
SO  - Niger Med J. 2012 Jul;53(3):121-5. doi: 10.4103/0300-1652.104378.