PMID- 23294796
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20231106
IS  - 1932-2968 (Electronic)
IS  - 1932-2968 (Linking)
VI  - 6
IP  - 6
DP  - 2012 Nov 1
TI  - Oral delivery of glucagon-like peptide-1 and analogs: alternatives for diabetes 
      control?
PG  - 1486-97
AB  - Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases worldwide. 
      Current treatments are often associated with off-target effects and do not 
      significantly impact disease progression. New therapies are therefore urgently 
      needed to overcome this social burden. Glucagon-like peptide-1 (GLP-1), an 
      incretin hormone, has been used to control T2DM symptomatology. However, the 
      administration of peptide or proteins drugs is still a huge challenge in the 
      pharmaceutical field, requiring administration by parenteral routes. This article 
      reviews the main hurdles in oral administration of GLP-1 and focuses on the 
      strategies utilized to overcome them.
CI  - (c) 2012 Diabetes Technology Society.
FAU - Araujo, Francisca
AU  - Araujo F
AD  - Department of Pharmaceutical Sciences, Centro de Investigacao em Ciencias da 
      Saude, Health Sciences Research Center,Instituto Superior de Ciencias da Saude, 
      CESPU, Gandra, Portugal.
FAU - Fonte, Pedro
AU  - Fonte P
FAU - Santos, Helder A
AU  - Santos HA
FAU - Sarmento, Bruno
AU  - Sarmento B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20121101
PL  - United States
TA  - J Diabetes Sci Technol
JT  - Journal of diabetes science and technology
JID - 101306166
RN  - 0 (Hypoglycemic Agents)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Glucagon-Like Peptide 1/analogs & derivatives/*pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
PMC - PMC3570891
EDAT- 2013/01/09 06:00
MHDA- 2013/08/29 06:00
PMCR- 2013/11/01
CRDT- 2013/01/09 06:00
PHST- 2013/01/09 06:00 [entrez]
PHST- 2013/01/09 06:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
PHST- 2013/11/01 00:00 [pmc-release]
AID - dst.6.6.1486 [pii]
AID - 10.1177/193229681200600630 [doi]
PST - epublish
SO  - J Diabetes Sci Technol. 2012 Nov 1;6(6):1486-97. doi: 10.1177/193229681200600630.