PMID- 23294928
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20211203
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 147
IP  - 3
DP  - 2013 Jun
TI  - Specific inflammasomes in complex diseases.
PG  - 223-8
LID - S1521-6616(12)00306-3 [pii]
LID - 10.1016/j.clim.2012.12.006 [doi]
AB  - Blocking the cytokines Interleukin-1beta (IL-1beta) and Interleukin-18 (IL-18) 
      benefits a diverse range of inflammatory pathologies. In each of these diseases, 
      different cytoplasmic innate immune receptors nucleate individual protein 
      complexes known as inflammasomes, to regulate the production of active IL-1beta or 
      IL-18. This review will outline the complex diseases where these cytokines are 
      pathogenic, and explain which inflammasome(s) may be responsible. For example, 
      inflammasomes nucleated by NLRP3 and NLRP6 integrate signals from metabolic and 
      commensal systems contributing to metabolic dysfunction and type 2 diabetes. On 
      the other hand, NLRP1 and AIM2 are more broadly implicated in autoimmunity and 
      allergy. Furthermore, each inflammasome has unique roles in pathogen recognition, 
      which may determine the outcome of polymicrobial infection and link different 
      infectious co-morbidities to chronic inflammatory disease. We can now imagine a 
      time when targeted inflammasome inhibitors will be employed in the clinic, 
      tailoring treatments to particular diseases, and perhaps individual patients.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Masters, Seth L
AU  - Masters SL
AD  - The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, 
      Australia. masters@wehi.edu.au
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121221
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (AIM2 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLR Proteins)
RN  - 0 (NLRP1 protein, human)
RN  - 0 (NLRP3 protein, human)
RN  - 0 (NLRP6 protein, human)
RN  - 0 (Nuclear Proteins)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/metabolism
MH  - Alzheimer Disease/genetics/immunology/metabolism
MH  - Animals
MH  - Apoptosis Regulatory Proteins/metabolism
MH  - Atherosclerosis/genetics/immunology/metabolism
MH  - Carrier Proteins/*metabolism
MH  - DNA-Binding Proteins
MH  - Diabetes Mellitus, Type 2/immunology/metabolism
MH  - Gout/genetics/immunology/metabolism
MH  - Humans
MH  - Inflammasomes/*immunology
MH  - Inflammatory Bowel Diseases/genetics/immunology/metabolism
MH  - Interleukin-18/*metabolism
MH  - Interleukin-1beta/*metabolism
MH  - Intracellular Signaling Peptides and Proteins/immunology/*metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein
MH  - NLR Proteins
MH  - Neoplasms/genetics/immunology/metabolism
MH  - Nuclear Proteins/genetics/immunology
MH  - Obesity/genetics/immunology/metabolism
EDAT- 2013/01/09 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/01/09 06:00
PHST- 2012/10/14 00:00 [received]
PHST- 2012/12/09 00:00 [revised]
PHST- 2012/12/11 00:00 [accepted]
PHST- 2013/01/09 06:00 [entrez]
PHST- 2013/01/09 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
AID - S1521-6616(12)00306-3 [pii]
AID - 10.1016/j.clim.2012.12.006 [doi]
PST - ppublish
SO  - Clin Immunol. 2013 Jun;147(3):223-8. doi: 10.1016/j.clim.2012.12.006. Epub 2012 
      Dec 21.