PMID- 23295361
OWN - NLM
STAT- MEDLINE
DCOM- 20130827
LR  - 20180822
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Linking)
VI  - 91
IP  - 3
DP  - 2013 Mar
TI  - Intestinal DC in migrational imprinting of immune cells.
PG  - 240-9
LID - 10.1038/icb.2012.73 [doi]
AB  - Dendritic cells (DCs) have a pivotal role in instructing antigen-specific immune 
      responses, processing and presenting antigens to CD4(+) and CD8(+) T cells and 
      producing factors capable to modulate the quality of T-cell responses. In this 
      review, we will provide an historic overview on the identification of the 
      mechanisms controlling lymphocyte migration into the largest immune organ of the 
      body: the gut, and we will describe how in recent years an unexpected role for 
      DCs has emerged as the architects in programming gut-homing immune cells. 
      Specifically, we will review how intestinal DCs utilize the dietary vitamin A 
      metabolite retinoic acid (RA) to program gut-homing lymphocytes and how 
      intestinal DCs acquire the unique capacity to become RA producers.
FAU - Stock, Angus
AU  - Stock A
AD  - Department of Microbiology and Immunology, The University of Melbourne, 
      Parkville, Victoria, Australia. astock@unimelb.edu.au
FAU - Napolitani, Giorgio
AU  - Napolitani G
FAU - Cerundolo, Vincenzo
AU  - Cerundolo V
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130108
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*physiology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cell Movement/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Intestinal Mucosa/cytology/*immunology
MH  - Vitamin A/*immunology
EDAT- 2013/01/09 06:00
MHDA- 2013/08/28 06:00
CRDT- 2013/01/09 06:00
PHST- 2013/01/09 06:00 [entrez]
PHST- 2013/01/09 06:00 [pubmed]
PHST- 2013/08/28 06:00 [medline]
AID - icb201273 [pii]
AID - 10.1038/icb.2012.73 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2013 Mar;91(3):240-9. doi: 10.1038/icb.2012.73. Epub 2013 Jan 
      8.