PMID- 23295397
OWN - NLM
STAT- MEDLINE
DCOM- 20130828
LR  - 20130307
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 243
DP  - 2013 Apr 15
TI  - The effects of enriched environment on BDNF expression in the mouse cerebellum 
      depending on the length of exposure.
PG  - 118-28
LID - S0166-4328(12)00837-6 [pii]
LID - 10.1016/j.bbr.2012.12.047 [doi]
AB  - Environmental enrichment (EE) has been proposed as a factor that improves 
      neuronal connectivity and brain plasticity. The induction of molecular mechanisms 
      that takes place in the cortex, nucleus accumbens and hippocampus resulting from 
      exposure to EE has been attributed partly to the role of neurotrophins as 
      brain-derived neurotrophic factor (BDNF). Recent data directly implicate this 
      neurotrophin in the modulation of plasticity changes in the cerebellum produced 
      by living under environmental enrichment. In the present study, we aimed to 
      assess the effects of different lengths of exposure to EE on cerebellar BDNF 
      expression and western blotting analysis. On the whole, the present data has 
      shown that BDNF increased under EE. However, changes in expression as a result of 
      extending the duration of EE were only seen in Purkinje neurons. In Purkinje 
      neurons, long-term exposure was required in order to fully express this 
      neurotrophin. These data support BDNF as one of the long-term plasticity 
      mechanisms induced by environment, suggesting that cerebellar plasticity can be 
      stimulated as a response to challenges generated by environment. Our findings 
      could have functional implications for various neurodegenerative disorders such 
      as spinocerebellar ataxias, autism, schizophrenia and certain prion 
      encephalopathies, most of them pathologies which have demonstrated to be 
      characterized by alterations in Purkinje neurons and to show a partial recovery 
      by exposure to EE.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Vazquez-Sanroman, D
AU  - Vazquez-Sanroman D
AD  - Area de Psicobiologia, Universidad Jaume I, Castellon de Plana, Spain.
FAU - Sanchis-Segura, C
AU  - Sanchis-Segura C
FAU - Toledo, R
AU  - Toledo R
FAU - Hernandez, M E
AU  - Hernandez ME
FAU - Manzo, J
AU  - Manzo J
FAU - Miquel, M
AU  - Miquel M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130104
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/*genetics
MH  - Cerebellum/cytology/*metabolism
MH  - *Environment
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neuronal Plasticity/*physiology
MH  - Neuropsychological Tests
MH  - Purkinje Cells/*metabolism
MH  - Random Allocation
MH  - Time Factors
EDAT- 2013/01/09 06:00
MHDA- 2013/08/29 06:00
CRDT- 2013/01/09 06:00
PHST- 2012/10/15 00:00 [received]
PHST- 2012/11/21 00:00 [revised]
PHST- 2012/12/27 00:00 [accepted]
PHST- 2013/01/09 06:00 [entrez]
PHST- 2013/01/09 06:00 [pubmed]
PHST- 2013/08/29 06:00 [medline]
AID - S0166-4328(12)00837-6 [pii]
AID - 10.1016/j.bbr.2012.12.047 [doi]
PST - ppublish
SO  - Behav Brain Res. 2013 Apr 15;243:118-28. doi: 10.1016/j.bbr.2012.12.047. Epub 
      2013 Jan 4.