PMID- 23295499
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20211021
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 37
IP  - 9
DP  - 2013 Sep
TI  - Obesogenic phenotype of offspring of dams fed a high multivitamin diet is 
      prevented by a post-weaning high multivitamin or high folate diet.
PG  - 1177-82
LID - 10.1038/ijo.2012.210 [doi]
AB  - BACKGROUND: High multivitamin (10-fold AIN-93G, HV) diets fed during pregnancy to 
      Wistar rats increase characteristics of metabolic syndrome in offspring when 
      weaned to the recommended vitamin (RV) diet. OBJECTIVE: To determine whether the 
      effects of HV gestational diets on obesogenic phenotypes in the offspring arise 
      as a consequence of altered hypothalamic control of feeding behavior and if their 
      increased food intake could be prevented by feeding them HV or high folate 
      (10-fold folate, HFol) diets. METHODS: Male offspring of dams fed HV diet during 
      pregnancy weaned to RV, HV or HFol diets were compared with those born to RV dams 
      and weaned to RV diet for 29 weeks. Food intake over 72 h and body weight were 
      measured bi-weekly and weekly, respectively. Glucose response to a glucose load 
      was measured at 18 weeks post weaning. Hypothalamic gene expression of 
      feeding-related neuropeptides including neuropeptide Y, pro-opiomelanocortin 
      (POMC), insulin receptor, leptin receptor, brain-derived neurotrophic factor 
      (BDNF), receptors for dopamine (DopaR1/2/5) and serotonin (SeroR1A/2A/2C), as 
      well as global DNA methylation and brain and plasma folate concentrations were 
      measured at 29 weeks post weaning. RESULTS: HV or HFol pup diets increased brain 
      and plasma folate concentrations and prevented the increase in food intake (5%, 
      P=0.03), body weight (8%, P=0.0006) and glucose response to a glucose load (36%, 
      P=0.02) found in those fed the RV diet. Expression of anorexigenic POMC (P=0.004) 
      and BDNF (P=0.02) was higher, and DopaR1 was lower (P=0.06) in pups fed the HV 
      diet. The HFol pup diet partially brought BDNF to the control level (P=0.02) and 
      lowered SeroR2A (P=0.008). Expression of other genes was unaffected. Global DNA 
      methylation was similar among the diet groups. CONCLUSION: The obesogenic 
      phenotype in offspring from HV-fed dams is prevented by feeding HV or HFol pup 
      diets, possibly due to post-weaning modulation of food intake regulatory 
      mechanisms.
FAU - Cho, C E
AU  - Cho CE
AD  - Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Sanchez-Hernandez, D
AU  - Sanchez-Hernandez D
FAU - Reza-Lopez, S A
AU  - Reza-Lopez SA
FAU - Huot, P S P
AU  - Huot PS
FAU - Kim, Y-I
AU  - Kim YI
FAU - Anderson, G H
AU  - Anderson GH
LA  - eng
GR  - 93624-1/CAPMC/CIHR/Canada
GR  - MOP-93624/CAPMC/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130108
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, Leptin)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Vitamins)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.7.10.1 (Receptor, Insulin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Biomarkers/metabolism
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Eating/*genetics
MH  - Feeding Behavior
MH  - Female
MH  - Folic Acid/administration & dosage/metabolism/*pharmacology
MH  - Gene Expression Regulation, Developmental
MH  - Hypothalamus/*metabolism
MH  - Male
MH  - Maternal Nutritional Physiological Phenomena/genetics
MH  - Metabolic Syndrome/etiology/genetics/*metabolism
MH  - Obesity/etiology/genetics/*metabolism
MH  - Phenotype
MH  - Pro-Opiomelanocortin/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, Insulin/metabolism
MH  - Receptors, Dopamine/metabolism
MH  - Receptors, Leptin/metabolism
MH  - Receptors, Serotonin
MH  - Vitamins/administration & dosage/*pharmacology
MH  - Weaning
PMC - PMC4954778
MID - CAMS4039
OID - NLM: CAMS4039
COIS- DISCLOSURE: The authors declare no conflict of interest. CONFLICT OF INTEREST The 
      authors declare no conflict of interest.
EDAT- 2013/01/09 06:00
MHDA- 2014/05/06 06:00
PMCR- 2016/07/20
CRDT- 2013/01/09 06:00
PHST- 2012/09/13 00:00 [received]
PHST- 2012/10/31 00:00 [revised]
PHST- 2012/11/18 00:00 [accepted]
PHST- 2013/01/09 06:00 [entrez]
PHST- 2013/01/09 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
PHST- 2016/07/20 00:00 [pmc-release]
AID - ijo2012210 [pii]
AID - 10.1038/ijo.2012.210 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2013 Sep;37(9):1177-82. doi: 10.1038/ijo.2012.210. Epub 2013 
      Jan 8.