PMID- 23296702 OWN - NLM STAT- MEDLINE DCOM- 20130507 LR - 20211021 IS - 1423-0380 (Electronic) IS - 1010-4283 (Linking) VI - 34 IP - 2 DP - 2013 Apr TI - The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. PG - 995-1004 LID - 10.1007/s13277-012-0636-4 [doi] AB - This study was undertaken to determine the differences in the clinicopathology and survival between synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC). Additionally, we analyzed the risk factors for single tumors to develop as sBBC or mBBC. Of the 190 bilateral breast cancer (BBC) cases, 84 cases were sBBC and 106 were mBBC. We defined sBBC as two tumors that developed within 12 months, while mBBC was defined as two tumors that developed over more than 12 months. The peak age of onset of the first mBBC tumors was significantly younger than that of sBBC tumors (p = 0.001). There was a higher concordance rate of ER/ER positivity and PR/PR positivity in the first and second tumors of sBBC than mBBC. The two sBBC breast cancers had relatively similar hormone conditions because of the low rate of ER and PR transformation from positive to negative or vice versa. We determined that patients who presented with extracapsular extension (p = 0.008) and ER positivity (p = 0.001) tend to have synchronous cancers, while patients with 3+ HER2 were more likely to develop metachronous tumors. The prognosis for mBBC was better than that for sBBC when the survival time of mBBC was measured from the initial observation of the first tumors. FAU - Liang, Xinrui AU - Liang X AD - The First Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment and Research center, Tianjin Medical University Cancer Institute and Hospital, West Beihuanhu Rd, Tianjin, 300060, People's Republic of China. FAU - Li, Danhua AU - Li D FAU - Geng, Wenwen AU - Geng W FAU - Cao, Xuchen AU - Cao X FAU - Xiao, Chunhua AU - Xiao C LA - eng PT - Journal Article DEP - 20130109 PL - Netherlands TA - Tumour Biol JT - Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine JID - 8409922 RN - 0 (Biomarkers, Tumor) RN - 0 (Receptors, Estrogen) RN - 0 (Receptors, Progesterone) RN - EC 2.7.10.1 (Receptor, ErbB-2) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Biomarkers, Tumor/metabolism MH - Breast Neoplasms/metabolism/*mortality/pathology MH - Female MH - Humans MH - Immunoenzyme Techniques MH - Middle Aged MH - Neoplasm Grading MH - Neoplasm Metastasis MH - Neoplasm Staging MH - Neoplasms, Second Primary/metabolism/*mortality/pathology MH - Prognosis MH - Receptor, ErbB-2/*metabolism MH - Receptors, Estrogen/*metabolism MH - Receptors, Progesterone/*metabolism MH - Retrospective Studies EDAT- 2013/01/09 06:00 MHDA- 2013/05/08 06:00 CRDT- 2013/01/09 06:00 PHST- 2012/10/22 00:00 [received] PHST- 2012/12/13 00:00 [accepted] PHST- 2013/01/09 06:00 [entrez] PHST- 2013/01/09 06:00 [pubmed] PHST- 2013/05/08 06:00 [medline] AID - 10.1007/s13277-012-0636-4 [doi] PST - ppublish SO - Tumour Biol. 2013 Apr;34(2):995-1004. doi: 10.1007/s13277-012-0636-4. Epub 2013 Jan 9.