PMID- 23297860
OWN - NLM
STAT- MEDLINE
DCOM- 20130502
LR  - 20130305
IS  - 1528-1167 (Electronic)
IS  - 0013-9580 (Linking)
VI  - 54
IP  - 3
DP  - 2013 Mar
TI  - Cognitive impairment and cortical reorganization in children with benign epilepsy 
      with centrotemporal spikes.
PG  - 487-94
LID - 10.1111/epi.12067 [doi]
AB  - PURPOSE: Benign epilepsy with centrotemporal spikes (BECTS) is associated with 
      mild cognitive deficits, especially language impairment. This study aimed to 
      clarify whether children with BECTS with left- or right-hemispheric, or bilateral 
      focus have specific neuropsychological language deficits when compared to healthy 
      controls, whether these deficits correlate functionally with language network 
      organization (typical vs. atypical), and whether cofactors such as duration, 
      handedness, and medication have a relevant impact on language reorganization 
      processes. METHODS: Twenty-seven patients and 19 healthy controls were examined 
      with several neuropsychological tests (German version of the Wechsler 
      Intelligence Scale for Children [WISC-IV], Regensburger verbal fluency test 
      [RWT], Corsiblock forward and backward and Hand-Dominanz-Test [HDT]) and with two 
      language paradigms on functional magnetic resonance imaging (fMRI): silent 
      reading of word-pairs and silent generation of simple sentences. KEY FINDINGS: 
      Although neuropsychological test results only differed by trend between BECTS 
      patients and controls, language laterality indices (LIs) in fMRI were 
      significantly lower in patients than in controls. In particular, the anterior 
      language network with Broca's area and the supplementary motor area (SMA) 
      revealed the lowest LIs and showed the most bilateral or right hemispheric 
      activations in the sentence generation task. Medication and duration of epilepsy 
      did not have any significant effect on language reorganization and patients' 
      performances. SIGNIFICANCE: Language reorganization in BECTS patients takes place 
      in bilateral or right hemispheric language networks, with a strong focus in 
      anterior language regions. These functional changes can be interpreted as 
      important compensatory strategies of the central nervous system (CNS) to 
      stabilize cognitive, especially language performance.
CI  - Wiley Periodicals, Inc. (c) 2013 International League Against Epilepsy.
FAU - Datta, Alexandre N
AU  - Datta AN
AD  - Division of Pediatric Neurology and Developmental Medicine, University Children's 
      Hospital, Basel, Switzerland. alexandre.datta@ukbb.ch
FAU - Oser, Nadine
AU  - Oser N
FAU - Bauder, Florian
AU  - Bauder F
FAU - Maier, Oliver
AU  - Maier O
FAU - Martin, Florence
AU  - Martin F
FAU - Ramelli, Gian Paolo
AU  - Ramelli GP
FAU - Steinlin, Maja
AU  - Steinlin M
FAU - Weber, Peter
AU  - Weber P
FAU - Penner, Iris-Katharina
AU  - Penner IK
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130107
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adolescent
MH  - Cerebral Cortex/*physiology
MH  - Child
MH  - Cognition Disorders/epidemiology/*physiopathology/*psychology
MH  - Epilepsy, Rolandic/epidemiology/*physiopathology/*psychology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Neuropsychological Tests
MH  - Photic Stimulation/methods
MH  - Psychomotor Performance/physiology
MH  - Wechsler Scales
EDAT- 2013/01/10 06:00
MHDA- 2013/05/03 06:00
CRDT- 2013/01/10 06:00
PHST- 2012/10/31 00:00 [accepted]
PHST- 2013/01/10 06:00 [entrez]
PHST- 2013/01/10 06:00 [pubmed]
PHST- 2013/05/03 06:00 [medline]
AID - 10.1111/epi.12067 [doi]
PST - ppublish
SO  - Epilepsia. 2013 Mar;54(3):487-94. doi: 10.1111/epi.12067. Epub 2013 Jan 7.