PMID- 23298491
OWN - NLM
STAT- MEDLINE
DCOM- 20130423
LR  - 20170214
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 25
IP  - 4
DP  - 2012 Oct-Dec
TI  - IL-18 level in patients undergoing coronary artery bypass grafting surgery or 
      valve replacement: which link with epicardial fat depot?
PG  - 1011-20
AB  - Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines 
      produced constitutively by different cell types and by adipose tissue. Due to the 
      link between obesity, inflammation and cardiovascular diseases, we aimed to 
      measure IL-18 circulating level in patients undergoing open-heart surgery both 
      for elective coronary artery bypass grafting (CABG) or for valve replacement 
      (VR), and we also evaluated whether epicardial adipose tissue (EAT) depot may be 
      a potential source of IL-18. Circulating IL-18 protein was quantified by 
      enzyme-linked immunosorbent assay. IL-18, IL-18 receptor 1 (IL-18 R1) and IL-18 
      receptor accessory protein (IL-18-RAP) gene expression in EAT depot were 
      evaluated by one colour microarray platform. EAT thickness was measured by 
      echocardiography. In this study we found that all cardiovascular patients (CABG 
      and VR) have increased circulating IL-18 level compared to healthy control 
      subjects (p < 0.0001), but no statistical significant difference was observed 
      between CABG and VR groups (p = 0.35). A great increase in the gene expression of 
      IL-18 (p < 0.05), IL-18 R1 (p < 0.01) and IL-18 RAP (p < 0.001) was 
      observed in EAT samples obtained from CABG vs VR patients. In conclusion, CABG 
      and VR patients had similar increased level of circulating IL-18 protein, but in 
      EAT depots isolated from CABG gene expression of IL-18, IL-18 R1 and IL-18-RAP 
      resulted higher than in VR patients. Future investigation on local IL-18 protein 
      production, its autocrine-paracrine effect and its correlation with plasmatic 
      IL-18 level could give more information on the relationship between IL-18 and 
      coronary artery disease.
FAU - Dozio, E
AU  - Dozio E
AD  - Dipartimento di Scienze Biomediche per la Salute, Universita degli Studi di 
      Milano, Milan, Italy. elena.dozio@unimi.it
FAU - Dogliotti, G
AU  - Dogliotti G
FAU - Malavazos, A E
AU  - Malavazos AE
FAU - Bandera, F
AU  - Bandera F
FAU - Cassetti, G
AU  - Cassetti G
FAU - Vianello, E
AU  - Vianello E
FAU - Zelaschi, R
AU  - Zelaschi R
FAU - Barassi, A
AU  - Barassi A
FAU - Pellissero, G
AU  - Pellissero G
FAU - Solimene, U
AU  - Solimene U
FAU - Morricone, L
AU  - Morricone L
FAU - Sigruener, A
AU  - Sigruener A
FAU - Tarabin, V
AU  - Tarabin V
FAU - Schmitz, G
AU  - Schmitz G
FAU - Menicanti, L
AU  - Menicanti L
FAU - Corsi Romanelli, M M
AU  - Corsi Romanelli MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Adult
MH  - Aged
MH  - *Coronary Artery Bypass
MH  - Female
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Interleukin-18/*blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Pericardium/*metabolism
MH  - Waist Circumference
EDAT- 2013/01/10 06:00
MHDA- 2013/04/24 06:00
CRDT- 2013/01/10 06:00
PHST- 2013/01/10 06:00 [entrez]
PHST- 2013/01/10 06:00 [pubmed]
PHST- 2013/04/24 06:00 [medline]
AID - 18 [pii]
AID - 10.1177/039463201202500418 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):1011-20. doi: 
      10.1177/039463201202500418.